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2010 Oct-Dec; Vol 1, No 4:e1 |
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The Effect of Locally Delivered Doxycycline in the Treatment of Chronic Periodontitis. A Clinical and Microbiological Cohort Study J Oral Maxillofac Res 2010 (Oct-Dec);1(4):e1 doi:10.5037/jomr.2010.1401 |
The Effect of Locally Delivered Doxycycline in the Treatment of Chronic Periodontitis. A Clinical and Microbiological Cohort Study
1Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Greece
Corresponding author:
26-30 Meg. Alexandrou Str, Kalamaria 55134, Thessaloniki
Greece
Phone: +302310444467
Fax: +302310444467
E-mail: iioann@otenet.gr
ABSTRACT
Objectives: To evaluate the efficacy of locally delivered doxycycline as an adjunct to non-surgical treatment with the use of an ultrasonic device compared to scaling and root planing using hand instruments, by means of clinical and microbiological criteria.
Material and Methods: Thirty three patients with chronic periodontitis participated in this cohort study and were divided into two groups. Patients in control group received scaling and root planing using hand instruments, whereas patients in control group received ultrasonic debridement and 8.8% doxycycline gel was applied after initial therapy and at 3 months at preselected sites. Clinical recordings concerning probing pocket depth, clinical attachment level, plaque index and gingival bleeding index were performed at baseline, 3 and 6 months after baseline. Subgingival samples were analysed using the "checkerboard" DNA-DNA hybridisation technique for Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola.
Results: Both treatments resulted in significant improvement in all clinical recordings. Six months after the treatment a statistically significant decrease was observed for Porphyromonas gingivalis in both of groups and Treponema denticola in the control group (P < 0.05). No inter-group differences were observed (P < 0.05).
Conclusions: Both treatment modalities provided comparable clinical and microbiological results in the treatment of chronic periodontitis.
J Oral Maxillofac Res 2010 (Oct-Dec);1(4):e1
doi:10.5037/jomr.2010.1401
Accepted for publication: 31 July 2010
Keywords: chronic periodontitis; doxycycline; root scaling; root planing; debridement; cohort studies.
To cite this article: The Effect of Locally Delivered Doxycycline in the Treatment of Chronic Periodontitis. A Clinical and Microbiological Cohort Study. J Oral Maxillofac Res 2010;1(4):e1 URL: http://www.ejomr.org/JOMR/archives/2010/4/e1/v1n4e1ht.htm |
Received: 17 June 2010 | Accepted: 31 July 2010 | Published: 1 January 2011
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2011.