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Review of MicroRNA Proposed Target Genes in Oral Cancer. Part II J Oral Maxillofac Res 2011 (Apr-Jun);2(2):e2 doi:10.5037/jomr.2011.2202 |
Review of MicroRNA Proposed Target Genes in Oral Cancer. Part II
1Department of Oral and Maxillofacial Surgery, University of Illinois at Chicago, USA.
2Center of Molecular Biology and Oral Diseases, College of Dentistry, University of Illinois at Chicago, USA.
3Cancer Center, University of Illinois at Chicago, USA.
4Department of Periodontics, College of Dentistry, University of Illinois at Chicago, USA.
Corresponding author:
Department of Oral and Maxillofacial Surgery
University of Illinois at Chicago
801 S. Paulina Street, MC 835, Chicago, Illinois, 60612-7210
USA
Phone: 312-996-1052
Fax: 312-996-5987
E-mail: ga1@uic.edu
ABSTRACT
Objectives: Cancer is the product of alterations in oncogenes, tumour suppressor genes and most recently microRNA genes not as a single event or single change but rather as a multistep process. The role of microRNA genes in carcinogenesis is recently explored and appears to be an early event in the pathogenesis of this as well as other disease processes and occurs via gene regulation by their own products, the microRNAs. The purpose of this article was to review the literature concerning MicroRNA proposed target genes in oral cancer.
Material and Methods: A review of the available literature from 2000 to 2011 regarding the potential roles assumed by microRNAs in oral cancer was undertaken using PubMed, Medline, Scholar Google and Scopus. Keywords for the search were: microRNA and oral cancer and target genes, microRNA deregulation and oral cancer, microRNA and carcinogenesis in the head and neck/oral cavity. English language full length articles were reviewed.
Results: Several microRNAs deregulated in oral cancer have been functionally validated and their exact target genes have been identified. Furthermore the carcinogenesis pathways impacted by these alterations has been proposed for some of these microRNAs.
Conclusions: The expanding knowledge of specific roles of certain microRNAs is further contributing to our understanding of the complexity of tumour progression and behaviour. Consideration of this information and incorporation into treatment modalities through targeted therapy could potentially enhance our abilities to improve outcome especially when other established therapies have failed.
J Oral Maxillofac Res 2011 (Apr-Jun);2(2):e2
doi:10.5037/jomr.2011.2202
Accepted for publication: 19 April 2011
Keywords: oral cancer; head and neck cancer; ; gene targeting; carcinogenesis tests.
To cite this article: Review of MicroRNA Proposed Target Genes in Oral Cancer. Part II. J Oral Maxillofac Res 2011;2(2):e2 URL: http://www.ejomr.org/JOMR/archives/2011/2/e2/v2n2e2ht.htm |
Received: 16 March 2011 | Accepted: 19 April 2011 | Published: 1 July 2011
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2011.