Castro et al. 2003 [38] |
2:1 allocation to active group based on size of tumour |
Double blinded. Physicians, patients and sponsor unaware of
allocation |
Yes |
90 (60 active, 30 placebo) |
No statistically significant difference |
None |
Georgiou et al. 2000 [39] |
Not specified |
Single blinded. Not specified |
Yes |
Not specified |
No statistically significant difference |
Trained person in community not specified |
Jovic et al. 2008. [40] |
Not specified |
Single blinded Not specified |
Yes |
Not specified |
No statistically significant difference |
None |
McNeely et al. 2004 [47] |
Computer generated code |
No blinding |
Yes |
20 (10 active exercise, 10 control) |
More stages III and IV in active exercise group more stages I and
IV in control group |
None |
McNeely et al. 2008 [27] |
Computer generated code |
Single blinded. Independent assessors |
Yes |
60 (30 active PRET, 30 control) |
No statistically significant difference |
None |
Pfister et al. 2010 [48] |
Computer generated code |
Single blinded. Patients unaware of group |
Yes |
58 |
Male > Female in control group. Uneven spread of histological
diagnoses |
None |
Plantevin et al. 2007 [41] |
Sealed coded envelopes |
Double blind. Independent anaesthetist and nurses. Patients sedated
and separated |
Yes |
42 (21 MNB, 21 placebo) |
Longer surgeries in MNB group |
None |
Roussier et al. 2006 [42] |
Sealed coded envelopes |
Double blind. Nursing staff administered pain relief - not aware of
allocation |
Yes |
48 (24 epidural, 24 I.V) |
No statistically significant difference |
None |
Saxena et al. 1994 [43] |
Not specified |
Double blinded double dummy technique |
Yes |
Not mentioned |
No statistically significant difference |
Not pharmacologically comparable doses of intervention |
Singhal et al. 2006 [44] |
Sealed envelope containing random allocations |
Single blinded. VAS score assessed by blinded observer. Patients
and staff aware of group |
Yes |
Not specified |
No statistically significant difference |
Administration not described for IV morphine group |
Werner et al. 2002 [45] |
2:1 allocation. No method mentioned |
Double blinded - identical packaging of syringes |
Yes |
90 (60 active, 30 placebo) |
Male > Female in placebo group. More 1 grade tumours in active,
metastases in placebo |
Any volume of gel up to 10 ml used |
Wittekindt et al. 2006 [46] |
Nurse assigned patients to different groups |
Double blinded Physician and patient unaware of dose concentration |
Yes |
Not specified |
No statistically significant difference (Raw data not presented) |
None |
Yagi et al. 1997 [35] |
No information |
No information |
Yes |
No information |
No statistically significant difference |
No information |