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Efficacy of Platelet-Rich-Plasma (PRP) and Highly Purified Bovine Xenograft (Laddec®) Combination in Bone Regeneration after Cyst Enucleation: Radiological and Histological Evaluation J Oral Maxillofac Res 2013 (Jul-Sep);4(3):e3 doi:10.5037/jomr.2013.4303 |
Efficacy of Platelet-Rich-Plasma (PRP) and Highly Purified Bovine Xenograft (Laddec®) Combination in Bone Regeneration after Cyst Enucleation: Radiological and Histological Evaluation
1Department of Oral and Maxillofacial Surgery, Catania University, Catania, Italy.
2Freelance Researcher, S.C.S., Scientific Consulting Services, Rome, Italy.
Corresponding author:
S.C.S., Scientific Consulting Services
Paolo Emiio 7, int 9
00144 Rome
Italy
Phone: (+39) 342-5224458
E-mail: renzoguarnieri@gmail.com
ABSTRACT
Objectives: The purpose of the present study was to evaluate the efficacy of adding platelet-rich plasma (PRP) to a new highly purified bovine allograft (Laddec®) in the bone regeneration of cystic bony defects augmented following cystectomy.
Material and Methods: Study sample included 20 patients undergoing cystectomy in which the bone defect was filled with PRP and Laddec®. All patients were examined with periapical radiographs before operation and at follow-up. After 3 months, at re-entry surgery for implant placement, bone core was taken for histological and histomorphometric analysis.Results: The postoperative successive radiographs showed a good regeneration of bone in the height of bony defects with application of PRP to bone graft. By the first postoperative month, about 48% of the defect was filled, which gradually increased in each month and showed about 90% of defect-fill by 6 months. Histological and histomorphometric analysis, showed a significant presence of bone tissue and vessels, with newly formed bone in contact with anorganic bone particles. The mean volume of vital bone was 68 ± 1.6% and the mean percentage of vital bone was 48 ± 2.4%. The mean percentage of inorganic particles in tissues was 20 ± 1.2% of the total volume. All the samples analyzed did not evidence the presence of inflammatory cells.
Conclusions: The results of this study showed how the use of Laddec® in association with platelet-rich plasma allows bone regeneration and has a potential for routine clinical use for regeneration of cystic bony defects.
J Oral Maxillofac Res 2013 (Apr-Jun);4(3):e3
doi:10.5037/jomr.2013.4303
Accepted for publication: 26 August 2013
Keywords: platelet-rich plasma; sintered bovine bone true bone ceramics; cystectomy; histology; xenograft.
To cite this article: Efficacy of Platelet-Rich-Plasma (PRP) and Highly Purified Bovine Xenograft (Laddec®) Combination in Bone Regeneration after Cyst Enucleation: Radiological and Histological Evaluation. J Oral Maxillofac Res 2013;4(3):e3 URL: http://www.ejomr.org/JOMR/archives/2013/3/e3/v4n3e3ht.htm |
Received: 3 July 2013 | Accepted: 26 August 2013 | Published: 1 October 2013
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2013.