Study Study design Results Conclusions
Sexton et al [2] 6-month case-controlled study of adults with chronic periodontitis. IL-1β levels decreased significantly in response to periodontal therapy. Potential utility for monitoring periodontal disease status.
Rosa et al. [7] Analysis of proteome results using the OralOme database IL-1β proposed to be promising but data are scarce. Further quantitative proteomic studies are needed.
Ma et al. [13] Meta-analysis of 20 case-controlled studies. Association of the IL-1β (3953/4) C→T polymorphism with chronic periodontitis in Asians. IL-1β (3953/4) C→T polymorphism probably increases the risk of chronic periodontitis in Asians.
Zhu et al. [14] Investigation of systemic and local levels of IL-1β, MCP-1, VEGF, PDGFin patients with periodontitis and coronary heart disease. IL-1β concentrations in the serum and gingival crevicular fluid of the three diseased groups were significantly higher than those in the control group. IL-1β could play a key role and can be considered a biomarker in the progression of coronary heart disease and chronic periodontitis.
Oh et al. [15] Effects of periodontal therapy on clinical parameters and IL-1β levels in patients with chronic periodontitis. IL-1β concentration was lower at 2 and 4 months after initial therapy at all sites. These results suggest that IL-1β level in samples reflect disease severity.
Miller et al. [16] Levels of IL-1β, MMP-8, and OPG in whole saliva of 57 adults in a case-control trial. Mean levels of IL-1βin saliva were significantly higher in case subjects than in controls. Salivary levels of IL-1β appear to serve as biomarkers of periodontitis.
Ng et al. [17] Alveolar bone loss and concentration of host-derived bone resorptive factors in saliva of 110 untreated dental patients in a cross-sectional study. IL-1β levels associated with increased bone loss score. Biomarkers in saliva may serve as a useful tool to monitor and predict periodontal diseases.
Scannapieco
et al. [18] 		Association of salivary biomarkers with alveolar bone loss from 1,256 post-menopausal women in a case-control study. Positive association between alveolar bone loss and salivary concentrations of IL-1β. Salivary biomarkers measured at baseline may serve to predict future alveolar bone loss.
Reinhardt
et al. [19] 		Correlation of salivary biomarkers and bone resorption in a longitudinal trial. Increasing IL-1β levels in the first year were associated with increased odds of subsequent periodontal attachment loss. Elevated biomarkers have the potential to identify patients vulnerable to periodontitis.