Table 2

Study	Groups	Description of affected sites						Implant characteristics			Prosthetic factors				Additional info
Study	Groups	PDs, mm	RB loss (SD), mm	BOP	Exudate	CAL (SD), mm	Recession (SD), mm	Systems	Time in function	Surface	Screwed/ cemented	Internal/ external	Splinted/ non splinted	Restoration type	Additional info
Arisan et al. [20]	Control	4 to 6	< 3 mm MBL	Yes	And/or suppuration	NA	NA	Multiple	19.4 months	Rough (acid etching and sand blasting)	Cemented	NA	NA	Fixed metal-ceramic prostheses	Suprastructures removed for measurements
Arisan et al. [20]	Test	4 to 6	< 3 mm MBL	Yes	And/or suppuration	NA	NA	Multiple	19.4 months	Rough (acid etching and sand blasting)	Cemented	NA	NA	Fixed metal-ceramic prostheses	Suprastructures removed for measurements
Bassetti et al. [21]	Control: LDD	4 to 6	0.5 to 2	Yes	NA	2.72 (0.72)	1.68 (1.04)	Straumann tissue level	7.2 (2.6 - 15) years	SLA	Screwed	NA	NA	NA	NA
Bassetti et al. [21]	Test: PDT	4 to 6	0.5 to 2	Yes	NA	2.66 (0.73)	1.53 (0.91)	Straumann tissue level	7.3 (4 - 14.8) years	SLA	Screwed	NA	NA	NA	NA
Esposito et al. [22]	Control	Deepest pocket only: 6.45	Mean 4.73 (2.11)	Yes	Pus exudation and/or soft tissue swelling and/or soft tissue redness	NA	NA	NA	6.13 years	NA	NA	NA	NA	NA	In some of the Sx treated cases, unsupported threads were removed and polished based on the clinician's decision
Esposito et al. [22]	Test	Deepest pocket only: 6.23	Mean 4.4 (1.58)	Yes		NA	NA	NA	5.65 years	NA	NA	NA	NA	NA
Hallstrom et al. [23]	Control	≥ 4	< 2mm bone loss	Yes	And/or suppuration	NA	NA	Multiple	10.9 years	NA	Cemented: 52.6%; Screwed: 47.4%	NA	NA	NA	NA
Hallstrom et al. [23]	Test	≥ 4	< 2mm bone loss	Yes	And/or suppuration	NA	NA	Multiple	10 years	NA	Cemented: 59.1%; Screwed: 40.9%	NA	NA	NA	NA
John et al. [24]	AAD	≥ 4	Loss of supporting bone ≤ 30%	Yes	Yes	5.2 (1.9)	1.5 (1.4)	Multiple	NA	Machined surface, microrough surface	Screwed	NA	Single tooth and bridgework restorations	NA	Without overhangings or margins
John et al. [24]	MD (carbon curettes + local antiseptic therapy)	≥ 4	Loss of supporting bone ≤ 30%	Yes	Yes	5 (1.5)	1 (1.1)	Multiple	NA	Machined surface, microrough surface	Screwed	NA	Single tooth and bridgework restorations	NA	Without overhangings or margins
Machtei et al. [25]	Control	6 to 10	≥ 2	Yes	NA	7.63 (0.3)	NA	NA	NA	Exclude Titanium Plasma-sprayed or hydroxylapatite coated implants	NA	NA	NA	NA	NA
Machtei et al. [25]	Test	6 to 10	≥ 2	Yes	NA	7.88 (0.2)	NA	NA	NA		NA	NA	NA	NA	NA
Persson et al. [26]	Er:YAG laser	≥ 5	≥ 2	Yes	And/or suppuration	NA	NA	NA	NA	Machined surfaces and medium-rough surfaces	NA	NA	NA	NA	Superstructures were removed to enhance assessments of PD and BOP and to improve the ability to collect bacterial samples.
Persson et al. [26]	AAD subgingival polishing	≥ 6	≥ 2	Yes	And/or suppuration	NA	NA	NA	NA	Machined surfaces and medium-rough surfaces	NA	NA	NA	NA
Riben-Grundstrom et al. [27]	Glycine powder air-polishing	≥ 4	≤ 2	Yes	And/or suppuration	NA	NA	Multiple	NA	NA	NA	NA	NA	NA	NA
Riben-Grundstrom et al. [27]	Ultrasonic debridement	≥ 4	≤ 2	Yes	And/or suppuration	NA	NA	Multiple	NA	NA	NA	NA	NA	NA	NA
Swierkot et al. [28]	Sonic toothbrush group	≥ 5	< 1	Yes/ no	NA	4.64	1.24	Nobel Replace Straight Groovy	At least 12 months	Rough	Screwed	NA	NA	Single implant or fixed prosthesis	NA
Swierkot et al. [28]	Manual toothbrush group	≥ 6	< 1	Yes/ no	NA	4.41	1.28	Nobel Replace Straight Groovy	At least 13 months	Rough	Screwed	NA	NA	Single implant or fixed prosthesis	NA
Gomes et al. [29]	Test	2.23 (0.09)	NA	Yes	NA	NA	NA	Nobel Biocare	5.7 (2.5) years	NA	NA	NA	NA	NA	NA
Corbella et al. [30]	Mucositis	NA	NA	Bleeding index ≥ 2	NA	NA	NA	NA	NA	NA	NA	NA	NA	Immediately loaded full-arch rehabilitation	NA
Corbella et al. [30]	Peri-implantitis	> 4	NA	Bleeding index ≥ 2	NA	NA	NA		NA	NA	NA	NA	NA	Immediately loaded full-arch rehabilitation	NA
Costa et al. [31]	Control	> 5	No	Yes	Yes	NA	NA	Multiple	80.5 months	NA	NA	NA	NA	Single crowns and/ or fixed partial prosthetic	NA
Costa et al. [31]	Test	> 5	No	Yes	Yes	NA	NA	Multiple	77.4 months	NA	NA	NA	NA	Single crowns and/ or fixed partial prosthetic	NA
Deppe et al. [32]	Moderate bone loss	< 5	3.9 (0.8)	Yes	NA	3.8 (1.3)	0.5 (0.5)	NA	NA	NA	NA	NA	NA	NA	All restorations were left in situ
Deppe et al. [32]	Severe bone lost	5 to 8	6.8 (0.8)	Yes	NA	6.7 (0.9)	0.9 (1.2)	NA	NA	NA	NA	NA	NA	NA	All restorations were left in situ
Schwarz et al. [33]	MD + local antiseptic (MD + CHX)	NA	No	Yes	No	NA	NA	Zirconia implants (ZV4, Zircon Vision GmbH, Wolfratshausen, Germany)	NA	Modified (roughness: Ra = approx. 7 μm/ Rz = approx. 41 μm)	Screwed	NA	NA	NA	NA
Schwarz et al. [33]	Er:YAG laser therapy	≥ 6	Changes in RB level	Yes	And/or suppuration	NA	NA		NA	Modified (roughness: Ra = approx. 7 μm/ Rz = approx. 42 μm)	Screwed	NA	NA	NA	NA

AAD = air-abrasive device; BOP = bleeding on probing; CAL = clinical attachment level; CHX = chlorhexidine digluconate; LD = local delivery; MBL = marginal bone level; MD = mechanical debridement; NA = not available; PD = probing depth; PDT = photodynamic therapy; RB = radiographic bone; SD = standard deviation; SLA = sandblasted and acid-etched implant.