Table 1. | Studies included in the meta-analysis |
| Study |
Year of publication |
Materials and methods | Outcome measures | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Animal type (n) |
Cell source |
Defect type (dimensions) |
Treatment duration in weeks |
Scaffold | Treatment groups |
Number of defects treated |
Periodontal ligament regeneration, mean (SD) |
Alveolar bone regeneration, mean (SD) |
Cementum regeneration, mean (SD) |
|||
| Jiang et al. [62] | 2016 |
Male Beagle dogs.
6 - 8 months of age (n = 6) |
Periodontal ligament |
3-wall intrabony periodontal defect (H x W x L = 5 x 4 x 3 mm) |
12 | Collagen sponge | PDLCs + collagen membrane | 9 | No data | 29.1 (6.6)% | 29.2 (16.4)% | |
| Control | 9 | 15.2 (4.9)% | 19.4 (4.3)% | |||||||||
| Nuñez et al. [63] | a | 2012 |
Adult Beagle dogs.
1 year old (n = 4) |
Periodontal ligament and cementum |
3-wall intrabony periodontal defect (H x W x L = 4 x 4 x 4 mm) |
12 | Collagen sponge | CSCs + collagen sponge | 8 | No data | 2.6 (0.4) mm | 4 (0.6) mm |
| b | PLDCs + collagen sponge | 8 | 3.1 (1.1) mm | 4.1 (1) mm | ||||||||
| a,b | Control | 8 | 2.6 (0.7) mm | 1.6 (0.4) mm | ||||||||
| Liu et al. [64] | 2008 |
Miniature pigs.
12 months old (n = 12) |
Periodontal ligament |
3-wall intrabony periodontal defect (H x W x L = 7 x 3 x 5 mm) |
12 | HA/TCP | PDLSC + HA/TCP | 24 | No data | 3.5 (0.7) mm | No data | |
| Control | 12 | 0.5 (0.4) mm | ||||||||||
| Jiang et al. [65] | 2010 |
Adult Beagle dogs (n = 4) |
Alveolar periosteum |
Class III furcation defect (H x W = 4 x 3 mm) |
12 | β-TCP | APSCs + β-TCP | 4 | 33.6 (13.8)% | 60.2 (18.2)% | 50.8 (8.2)% | |
| Control | 4 | 17.7 (5.4)% | 22.6 (7.3)% | 31.7 (12.9)% | ||||||||
| Park et al. [66] | a | 2011 |
Adult Beagle dogs (n = 8) |
Periodontal ligament and dental pulp |
Circumferential periodontal defect (W = 3 mm) |
8 | No scaffold | PDLSCs | 8 | No data | 82.8 (7.9)% | No data |
| b | DPSCs | 8 | 50.8 (9.6)% | |||||||||
| a,b | Control | 8 | 47.9 (13.4)% | |||||||||
| Suaid et al. [67] | 2011 |
Adult Beagle dogs (n = 7) |
Periodontal ligament |
Class II furcation defect (H x L = 5 x 2 mm) |
12 | Collagen sponge | PDLCs + collagen sponge | 7 | 7.3 (1) mm | 9 (2.3) mm2 | 8.1 (1.1) mm | |
| Control | 7 | 3.9 (1.2) mm | 7 (0.6) mm2 | 6 (1.5) mm | ||||||||
| Tsumanuma et al. [68] | a | 2011 |
Adult Beagle dogs (n = 4) |
Periodontal ligament; alveolar periosteum |
One-wall intrabony periodontal defect (H x W = 5 x 5 mm) |
8 | Woven polyglycolic acid | PDLCs + PGA | 4 | No data | 72.3 (32.6)% | No data |
| b | APSCs + PGA | 4 | 67.6 (21.6)% | |||||||||
| a,b | Control | 4 | 67.5 (14.3)% | |||||||||
| Suaid et al. [69] | 2012 |
Adult Beagle dogs (n = 7) |
Periodontal ligament |
Class III furcation defect (H = 5 mm) |
12 | Collagen sponge | PDLCs + Sponge + GTR | 7 | 3.4 (1.4) mm | 5.5 (1.6) mm | 4.8 (0.6) mm | |
| Control | 7 | 0.7 (0.6) mm | 1.9 (1) mm | 1.7 (0.6) mm | ||||||||
| Khorsand et al. [70] | 2013 |
Male, Mongrel dogs. 1 - 2 years of age (n = 10) |
Dental pulp |
3-wall intrabony periodontal defect (H x W x L = 5 x 8 x 3 mm) |
8 | Bio-Oss | DPSCs + Bio-Oss | 10 | 3.3 (1.1) mm | 3.6 (1.1) mm | 3.8 (1.3) mm | |
| Control | 10 | 1.8 (1.3) mm | 3.1 (0.8) mm | 2.4 (1.4) mm | ||||||||
| Tobita et al. [71] | 2013 |
Beagle dogs.
9 - 10 months old (n = 8) |
Adipose tissue |
Class III furcation defect (H = 5 mm) |
8 | PRP | ASC + PRP | 8 | No data | 63.6 (8.6)% | 84.7 (3.2)% | |
| Control | 8 | 40.3 (7.6)% | 61.7 (10.5)% | |||||||||
n = number of animals; SD = standard deviation; PDLCs = periodontal ligament stem cells; DPSCs = dental pulp stem cells; ASC = adipose tissue stem cells; PRP = platelet-rich plasma; GTR = guided tissue regeneration; CSCs = cementum stem cells; PGA = woven polyglycolic acid; APSCs = alveolar periosteal stem cells; β-TCP = β-tricalcium phosphate; HA/TCP = hydroxyapatite/tricalcium phosphate.
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