Case
(Age, Sex)		 Site of lesions
(TNM classification)		 Histological diagnosis
(pre-PDT/post-PDT)		 Mean of NA
(μm2; pre-PDT/
post-PDT)		 NACV
(%; pre-PDT/
post-PDT)		 PCNA LI
(%; pre-PDT/
post-PDT)		 Follow-up or
recurrent
term		 Recurrence
1 (56, F) tongue (T2N0M0) SCC/ED, moderate 57.7/82.2a 28.4/27.0 20.5/20.0 30 months +
2 (90, F) buccal mucosa (T2N0M0) SCC/ED, moderate 105.2/106.8 19.9/27.4 17.2/16.7 15 months +
3 (69, F) i) lt. buccal mucosa (T1N0M0)
ii) rt. lower gingiva (T1N0M0)
iii) rt. buccal mucosa (T1N0M0)		 SCC/ED, severe
SCC/gingivitis
SCC/ED		 60.4/97.0a
93.7/96.5
90.2/85.4		 32.5/22.8
36.2/54.3
44.6/26.6		 36.3/20.7
27.3/25.1
22.7/7.7		 11 months
37 months
37 months		 +
-
-
4 (83, M) hard palate (T2N0M0) SCC/stomatitis 108.8/84.3a 38.6/27.4 44.0/21.1 15 months +
5 (70, M) oral floor (T2N0M0) SCC/stomatitis 95.2/65.8a 37.3/32.1 22.5/10.8 4 months +
6 (63, F) tongue (T2N0M0) SCC/ED, moderate 87.8/40.2a 32.1/36.7 19.8/16.6 44 months -
7 (80, F) hard palate (T1N0M0) SCC/stomatitis with
moderate ED		 66.0/64.6 43.7/19.5 41.9/18.8 24 months -
8 (85, F) upper gingival (T2N0M0) SCC/gingivitis 95.6/63.1a 34.2/25.8 52.7/17.0 22 months -
9 (75, M) buccal mucosa (T1N0M0) SCC/sialadenitis 127.2/24.6a 43.9/43.6 16.0/21.0 20 months -
10 (74, F) lower gingival (T1N0M0) SCC/gingivitis 82.3/53.8a 32.1/29.9 12.5/3.8 15 months -
11 (78, F) lower gingival (T1N0M0) SCC/gingivitis 97.8/59.7a 58.1/40.4 19.6/11.9 18 months -
12 (76, M) Tongue (T2N0M0) SCC/glossitis 96.0/81.1b 39.7/27.5 25.0/5.3 18 months -
13 (66, M) lower gingival (T3N0M0) verrucous carcinoma/ED,
severe		 158.8/35.0a 41.6/35.3 26.7/16.4 10 months -
14 (72, M) tongue ED, moderate/ED, mild 54.1/41.6a 35.9/32.0 49.9/41.7 19 months -
15 (29, F) tongue ED, mild/glossitis 87.1/71.2a 27.2/39.3 17.1/22.0 19 months -
16 (79, F) hard palate ED, mild /ED, mild 81.9/51.7a 15.8/21.0 25.3/17.9 30 months -
17 (65, F) tongue ED, severe/glossitis 103.5/43.7a 35.6/34.8 19.1/13.7 30 months +
18 (61, M) soft palate ED/stomatitis with mild ED 82.6/59.7a 39.6/23.9 43.5/37.5 33 months -
19 (70, F) buccal mucosa ED, moderate/ED, mild 82.2/80.2 26.2/22.2 35.4/37.1 16 months -
20 (67, M) tongue ED, mild/glossitis 95.6/74.0a 31.7/22.5 35.0/47.0 7 months -

aExistence of statistically significant differences, P < 0.0001.
bExistence of statistically significant differences, P < 0.0243.
F = female; M = male; SCC = squamous cell carcinoma; ED = epithelial dysplasia; NA = nuclear area; NACV = coefficient of variation of the nuclear area; PCNA LI = proliferating cell nuclear antigen labelling index; PDT = photodynamic therapy.