MicroRNAs deregulated in HNOCC |
Proposed Target gene(s) additional mechanisms and findings | Author / Year / Journal |
microRNA-184 | c-Myc | Wong et al. / 2008 / Clin. Cancer Research. |
micrRNA-133a and microRNA-133b |
PKM2 (pyruvate kinase type 2) |
Wong et al. / 2008 / Int. J. Cancer. |
microRNA-137 and microRNA-193a |
CDK6 (cyclin dependant kinase 6) |
Kozaki et al. / 2008 / Cancer Research. |
E2F transcription factor 6 Additionally it was demonstrated that these two microRNAs are tumour suppressors epigenetically silenced during oral carcinogenesis through DNA hypermethylation |
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microRNA-15a |
Cyclin E PKCa (protien kinase c alpha) down regulates microRNA-15a that directly inhibits cyclin E |
Cohen et al / 2009 / Cancer Research |
microRNA-21 |
TPM1 and PTEN (tropomyosin 1 and phosphatase tensin) Most likely actual role of microRNA-21 in tumorigenesis is accomplished by complex interactions with tumour / metastasis and suppressor genes |
Zhu et al. / 2007 / Biol. Chem. Li et al. / 2008 / Clin. Cancer Research. Chang et al. / 2008 / J. Dent. Res. |
microRNA-103 and microRNA-107 |
PDCD4 (programmed cell death protein 4) |
Ramdas et al. / 2008 / Head and Neck. |
TGFBR3 (tumour growth factor receptor beta 3) |
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microRNA-205 and let-7 |
DHFR (dihydrofolate reductase) |
Nakashima et al. / 2008 / Acta Otolar. |
let-7 has been associated in oral cancers with decreased survival in cases with the KRAS-LCS6 genotype variant | Christensen et al. / 2009 / Carcinogenesis. | |
microRNA-125b and microRNA-100 |
KLF13, CXCL11 and FOXA1 andEGFR3 (epidermoid growth factor receptor 3) |
Henson et al. / 2009 / Genes Chromosomes Cancer. |
microRNA-222 | MMP1 (matrix metalloproteinase 1) |
Liu et al / 2009 / Cancer Genom. Proteom. |
SOD2 (manganese superoxide dismutase 2) |
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microRNA-24 |
DND1 (dead end 1, an RNA binding protein which in turn regulates a group of downstream genes at post-transcriptional levels) |
Liu et al. / 2009/ FEBS letters. |
microRNA-7 |
IGF1R (insulin-like growth factor1 receptor) |
Jiang et al. / 2010 / Biochemical Journal. |
microRNA-138 |
GNAI2 (G protein alpha inhibiting activity polypeptide 2) |
Jiang et al. / 2010 / International J. of Cancer. |