MicroRNAs
deregulated
in HNOCC
Proposed Target gene(s) additional mechanisms and findings Author / Year / Journal
microRNA-184 c-Myc Wong et al. / 2008 / Clin. Cancer Research.
micrRNA-133a
and
microRNA-133b
PKM2
(pyruvate kinase type 2)
Wong et al. / 2008 / Int. J. Cancer.
microRNA-137
and
microRNA-193a
CDK6
(cyclin dependant kinase 6)
Kozaki et al. / 2008 / Cancer Research.
E2F transcription factor 6
Additionally it was demonstrated that these two microRNAs are tumour suppressors epigenetically silenced during oral carcinogenesis through DNA hypermethylation
microRNA-15a Cyclin E
PKCa (protien kinase c alpha) down regulates microRNA-15a that directly inhibits cyclin E
Cohen et al / 2009 / Cancer Research
microRNA-21 TPM1 and PTEN
(tropomyosin 1 and phosphatase tensin) Most likely actual role of microRNA-21 in tumorigenesis is accomplished by complex interactions with tumour / metastasis and suppressor genes
Zhu et al. / 2007 / Biol. Chem. Li et al. / 2008 / Clin. Cancer Research. Chang et al. / 2008 / J. Dent. Res.
microRNA-103
and
microRNA-107
PDCD4
(programmed cell death protein 4)
Ramdas et al. / 2008 / Head and Neck.
TGFBR3
(tumour growth factor receptor beta 3)
microRNA-205
and
let-7
DHFR
(dihydrofolate reductase)
Nakashima et al. / 2008 / Acta Otolar.
let-7 has been associated in oral cancers with decreased survival in cases with the KRAS-LCS6 genotype variant Christensen et al. / 2009 / Carcinogenesis.
microRNA-125b
and
microRNA-100
KLF13, CXCL11
and
FOXA1 andEGFR3 (epidermoid growth factor receptor 3)
Henson et al. / 2009 / Genes Chromosomes Cancer.
microRNA-222 MMP1
(matrix metalloproteinase 1)
Liu et al / 2009 / Cancer Genom. Proteom.
SOD2
(manganese superoxide dismutase 2)
microRNA-24 DND1
(dead end 1, an RNA binding protein which in turn regulates a group of downstream genes at post-transcriptional levels)
Liu et al. / 2009/ FEBS letters.
microRNA-7 IGF1R
(insulin-like growth factor1 receptor)
Jiang et al. / 2010 / Biochemical Journal.
microRNA-138 GNAI2
(G protein alpha inhibiting activity polypeptide 2)
Jiang et al. / 2010 / International J. of Cancer.