Expressing cells Functions
Matrix
metalloproteases
(MMPs)
Collagenases Interstitial collagenase (MMP-1) Macrophages Degrades non-mineralized extracellular matrix
Stimulates osteoclastogenesis
Collagenase of neutrophils (MMP-8) Polymorphonuclear leukocytes, macrophages Degrades gelatin, type I, II, III, IV and XI collagens
Collagenase-3 (MMP-13) Fibroblasts, epithelial cells, plasma cells Degrades type I, II, III, IV, IX, X and XIV collagens, gelatin, tenacin-C, fibronectin and proteoglycan core proteins
Gelatinases Gelatinase A (MMP-2) Epithelial cells, fibroblasts Degrades gelatin, fibronectin, elastin, laminin, collagen I, III, IV, V, VII, X, XI
Gelatinase B (MMP-9) Polymorphonuclear leukocytes, macrophages, T cells, mast cells, odontoblasts Degrades gelatin, elastin, type IV, V, VII, X, XI and XI collagens
Serine proteases Neutrophil elastase (NE) Polymorphonuclear leukocytes Degrades elastin, collagen, fibrinogen, hemoglobin, proteoglycans
Cathepsin G Polymorphonuclear leukocytes, monocytes, mast cells Degrades type III collagen and proteoglycan