Expressing cells | Functions | |||
---|---|---|---|---|
Matrix metalloproteases (MMPs) |
Collagenases | Interstitial collagenase (MMP-1) | Macrophages |
Degrades non-mineralized extracellular matrix
Stimulates osteoclastogenesis |
Collagenase of neutrophils (MMP-8) | Polymorphonuclear leukocytes, macrophages | Degrades gelatin, type I, II, III, IV and XI collagens | ||
Collagenase-3 (MMP-13) | Fibroblasts, epithelial cells, plasma cells | Degrades type I, II, III, IV, IX, X and XIV collagens, gelatin, tenacin-C, fibronectin and proteoglycan core proteins | ||
Gelatinases | Gelatinase A (MMP-2) | Epithelial cells, fibroblasts | Degrades gelatin, fibronectin, elastin, laminin, collagen I, III, IV, V, VII, X, XI | |
Gelatinase B (MMP-9) | Polymorphonuclear leukocytes, macrophages, T cells, mast cells, odontoblasts | Degrades gelatin, elastin, type IV, V, VII, X, XI and XI collagens | ||
Serine proteases | Neutrophil elastase (NE) | Polymorphonuclear leukocytes | Degrades elastin, collagen, fibrinogen, hemoglobin, proteoglycans | |
Cathepsin G | Polymorphonuclear leukocytes, monocytes, mast cells | Degrades type III collagen and proteoglycan |