cdk4 p16
Cytoplasmic Nuclear Cytoplasmic Nuclear
Oral lichen planus Cases with positive staining/total no. (%) 48/60 (80) 19/60 (31.7) 41/60 (68.3) 11/60 (18.3)
Mean of % no. of cells stained (SD)
Median (range)
19.6 (22) 3 (7.5) 16.4 (22.6) 3.9 (13)
11 (0 - 80) 0 (0 - 42) 5 (0 - 90) 0 (0 - 65)
Negative control
(normal mucosa)
Cases with positive staining/total no. (%)
P-valuea
0/10 (0) 4/10 (40) 0/10 (0) 0/10 (0)
0.0001 0.06 0.0002 0.31
Mean of % no. of cells stained (SD)
Median (range)
P-valueb
0 (0) 1.3 (0.2) 0 (0) 0 (0)
0 (0 - 0) 0 (0 - 4) 0 (0 - 0) 0 (0 - 0)
0.0001 0.17 < 0.0001 0.16
Positive control
(OSCC)
Cases with positive staining/total no. (%)
P-valuea
10/10 (100) 10/10 (100) 10/10 (100) 10/10 (100)
0.23 0.0001 0.03 0.0001
Mean of % no. of cells stained (SD)
Median (range)
P-valueb
74 (6.8) 74 (6.8) 80.9 (3.1) 80.9 (3.1)
74 (65 - 83) 74 (65 - 83) 81 (75 - 85) 81 (75 - 85)
< 0.001 < 0.001 < 0.001 < 0.001

aP value between oral lichen planus and normal mucosa group, Pearson Chi Square test.
bP value between oral lichen planus and oral squamous cell carcinoma group, Mann-Whitney U test.
P < 0.05 was considered statistically significant.
OSCC = oral squamous cell carcinoma; no. = number; SD = standard deviation.