HSC = hematopoietic stem cell; MCS = mesenchymal stem cell; OC = osteoclast; OB = osteoblast.
Active osteoclasts are characterized by a ruffled membrane, actin ring organization, expression of vitronectin receptors and cathepsin K (CATK), and are active on the bone resorption process.
Active osteoblasts express characteristic osteogenic markers, being responsible for the osteoid synthesis and its subsequent mineralization.
The intense cellular crosstalk develops within the frame of endocrine, paracrine and autocrine regulation.