Study Year of
publication
Study
design
NOP Materials and methods Outcome measures
MSFA RBH
(mm)
Type of grafting material Membrane Number of implants Prosthetic
solution
LOP (month) Survival of
implants (%)
Bone regeneration
(%)
Biologic and mechanical
complications
NFB NMT RG
Froum et al. [16] 1998 RCT 113 113 NR Combination of different grafting materials e-PTFE: 79 133 NR 6 - 9 99 17 - 33 NR NR
No membrane coverage: 34 82 96 9 - 19
Tarnow et al. [17] 2000 RCT, split-mouth 12 12 NR Combination of different grafting materials e-PTFE: 12 28 NR 7 - 13 100 26
(SD 15)
NR NR
No membrane coverage: 12 27 93 12
(SD 8)
Tawil et al. [24] 2001 RCT 29 30 4 - 8 Bio-Oss®: 100% Collagen
membrane: 15
29 Fixed prostheses 22.4
(12 - 40)
93 NR Mucosal tears: 5
No membrane coverage: 15 32 78
Wallace et al. [25] 2005 CCT 51 21 NR Bio-Oss®: 100%;
PABG: 20% and Bio-Oss®: 80%
e-PTFE: 21 46 NR 12 98 17 51 32 NR
37 Collagen
membrane: 37
83 98 18 56 26
6 No membrane coverage: 6 6 100 12 64 24
Choi et al. [26] 2009 RCT, split-mouth 6 12 NR Bio-Oss®: 100% Collagen membrane: 6 NR NR 8
(7 - 9)
NR 13a 36b 50c None
No membrane coverage: 6 12 55 33 Dehiscence: 1;
swelling: 1
Barone et al. [27] 2013 RCT 18 18 < 5 PABG: 50%;
MP3®: 50%
Collagen membrane: 9 NR NR 6 NR 31
(SD 16)
51
(SD 19)
18
(SD 20)
SMP: 1;
dehiscence: 1;
haematoma: 2
No membrane coverage: 9 28
(SD 19)
59
(SD 15)
13
(SD 12)
SMP: 2;
dehiscence: 1;
haematoma: 2
García-Denche
et al. [28]
2013 RCT, split-mouth 109 66 4 - 7 Bio-Oss®: 100% Collagen membrane: 66 278 Fixed prostheses or bar retention 12 96.1d 19
(SD 6)e
31
(SD 3)f
49
(SD 10)g
None
69 No membrane coverage: 69 94.2 15
(SD 5)
32
(SD 6)
56
(SD 21)
Displacement of grafting material: 4

aP = 0.937 (nonparametric Mann-Whitney U test); bP = 0.026 (nonparametric Mann-Whitney U test); cP = 0.093 (nonparametric Mann-Whitney U test); dP = 0.08 (Cohen´s f2 test); eP = 0.52 (non-parametric Wilcoxon t-test); fP = 1 (non-parametric Wilcoxon t-test); gP = 0.6 (non-parametric Wilcoxon t-test).
CCT = controlled clinical trial; e-PTFE = expanded polytetrafluoroethylene; LOP = length of observation period; MSFA = maxillary sinus floor augmentation; NFB = newly formed bone; NMT = non-mineralised tissue; NOP = number of patients; PABG = particulated autogenous bone graft; PIMBL = peri-implant marginal bone loss; RCT = randomised controlled trial; RG = residual graft; SMP = sinus membrane perforation; SD = standard deviation.