Table 1. | PICO framework of the framed clinical question |
| Patient, population, problem (P) | Individuals with trigeminal neuralgia |
| Intervention (I) | Botulinum toxin type A |
| Comparison (C) | Saline (NaCl) as a placebo |
| Outcome (O) | Presence or absence or reduction of pain |
| Study design (S) | Randomized, double-blind, placebo controlled trials |
| Focus questions | What is the efficacy and differences between botulinum toxin type A doses and side effects of botulinum toxin type A therapy in patients with trigeminal neuralgia? |
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