Table 1. | PICOS framework of the framed clinical question |
| Patients (P) | Patients suffering from haemophilia A, B, von Willebrand disease |
| Intervention (I) | Antifibrinolytic therapy and clotting factor replacement therapy |
| Comparison (C) | Between outcomes of local and systemic administration |
| Outcome (O) | Presence or absence of secondary haemorrhage |
| Study design (S) | Randomized and Non- Randomized controlled trials |
| Focus question | What is the preferred treatment plan for patients with inherited bleeding disorders and is local therapy enough to perform teeth extractions or systemic therapy is mandatory? |
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