Patients (P) Patients suffering from haemophilia A, B, von Willebrand disease
Intervention (I) Antifibrinolytic therapy and clotting factor replacement therapy
Comparison (C) Between outcomes of local and systemic administration
Outcome (O) Presence or absence of secondary haemorrhage
Study design (S) Randomized and Non- Randomized controlled trials
Focus question What is the preferred treatment plan for patients with inherited bleeding disorders and is local therapy enough to perform teeth extractions or systemic therapy is mandatory?