Appendix 2

Search	Query	Items found
#1	((((((((((((((((((((((((((((((("Maxillofacial Abnormalities"[Mesh]) OR ("Orthognathic Surgery"[Mesh] OR "Orthognathic Surgical Procedures"[Mesh])) OR ("Osteotomy, Le Fort"[Mesh])) OR ("Osteotomy, Sagittal Split Ramus"[Mesh])) OR (Facial deformit[Text Word])) OR (Orthognatic surg[Text Word])) OR (orthognathic surg[Text Word])) OR (Maxillofacial Surg[Text Word])) OR (Corrective jaw Surg[Text Word])) OR (Maxillary osteotom[Text Word])) OR (Mandibular osteotom[Text Word])) OR (Mandibular Reconstruct[Text Word])) OR (Maxillofacial osteotom[Text Word])) OR (Le Fort osteotom[Text Word])) OR (Sagittal split[Text Word])) OR (BSSO[Text Word])) OR (Dentofacial Deformit[Text Word])) OR (Dentofacial Abnormalit[Text Word])) OR (Dentofacial Malformation[Text Word])) OR (Maxillofacial Abnormalit[Text Word])) OR (Maxillofacial Deformit[Text Word])) OR (Maxillofacial Malformation[Text Word])) OR (orthognathic osteotom[tw])) OR (Maxillary surger[tw])) OR (Mandibular surger[tw])) OR (Le Fort I[tw])) OR (Le Fort 1[tw])) OR (LF1[tw])) AND (((((((((((("Computer Simulation"[Mesh]) OR ("Imaging, Three-Dimensional"[Mesh])) OR ("Surgery, Computer-Assisted"[Mesh])) OR ("User-Computer Interface"[Mesh])) OR (Virtual surgical plan[tw])) OR (virtual plan[tw])) OR (Three-dimensional[tw])) OR (Threedimensional[tw])) OR (Computer-assisted surg[tw])) OR (3-dimensional[tw])) OR (3dimensional[tw])) OR (3D[tw]))) AND (((((((((((Conventional[tw]) OR (Conventional surgical plan[tw])) OR classic[tw] OR (Traditional[tw])) OR (Traditional plan[tw])) OR (Two-dimensional[tw])) OR (Twodimensional[tw])) OR (2- dimensional[tw])) OR (2dimensional[tw])) OR (2D[tw])) OR (Model surg[tw])) OR (Mock surg[tw]))) AND (("randomized controlled trial"[Publication Type] OR "controlled clinical trial"[Publication Type] OR "randomized"[tw] OR "placebo"[tw] OR randomis*[tw] OR "drug therapy"[MeSH Subheading] OR "randomly"[tw] OR "trial"[tw] OR "groups"[tw]) NOT ("animals"[MeSH Terms] NOT "humans"[MeSH Terms])))	178