Study Year of publication Study
design 		Patients/implants ADs Gender Follow-up
perioda 		Survival rate of implants Survival rate of
suprastructures 		Crestal
bone lossa 		PI Success rate
n/n M/F Months % (n/n patients)
% (n/n implants) 		% (n/n patients)
% (n/n suprastructures) 		mm % (n/n patients)
% (n/n implants) 		% (n/n patients)
% (n/n implants)
Alsaadi et al. [4] 2008 RS 25/111 HT NR 24 NR
93.7% (104/111)c 		NR NR NR NR
Cillo et al. [36] 2019 CR 1/5 HT+UC 0/1 0.5 0% (0/1)
0% (0/5)
Early loss: 5
Late loss: 0 		Irr. NR 100% (1/1)b
100% (5/5) 		NR
Chochlidakis et al. [65] 2016 CR 1/6 HT+sSS+SLE 0/1 14 100% (1/1)
100% (6/6) 		100% (1/1)
100% (2/2) 		NR NR NR
Alsaadi et al. [67] 2008 RS NR/21 HT NR Up to prosthetic loading NR
100% (21/21)d 		NR NR NR NR
Nicoli et al. [76] 2017 RS 4/NR HT NR Range:
96 - 120 		100% (4/4)
NR 		NR NR 25% (1/4)
NR 		NR
Attard et al. [89] 2002 CCS 21/82 HT 0/21 Mean: 90 NR
96.3% (79/82)
Early loss: 2
Late loss: 1 		NR Mean: 0.05 NR NR
96.3% (79/82)e
29/81 Control group 0/29 Mean: 7.7 NR
97.5% (79/81)
Early loss: 2
Late loss: 0 		NR Mean: 0.04 NR NR
97.5% (79/81)e
Overall
HT - RS: 3
CR: 2
CCS: 1 		52/225 - Ratio: 0/23 Mean: 52.2 83.3% (5/6)
93.3% (210/225)
Of these: 46.7% (7/15) early loss 		100% (1/1)
100% (2/2) 		Mean: 0.05 40% (2/5)
100% (5/5) 		NR
96.3% (79/82)e
HT
+concomitant ADs 		- CR: 2 2/11 - Ratio: 0/2 Mean: 7.3 50% (1/2)
54.5% (6/11)
Of these: 100% (5/5) early loss 		100% (1/1)
100% (2/2) 		NR 100% (1/1)
100% (5/5) 		NR
Control group - CCS: 1 29/81 - Ratio: 0/29 Mean: 7.7 NR
97.5% (79/81)
Of these: 100% (2/2) early loss 		NR Mean: 0.04 NR NR
97.5% (79/81)e

a = weighted mean or median; b = submental abscess with extension to submandibular spaces; c = early loss NR; d = late loss NR; e = criteria by Zarb et al. [118].
ADs = autoimmune diseases; CCS = case-control study; CR = case report; Irr. = irrelevant; M/F = male/female; N = number; NR = not reported; PI = peri-implantitis; RS = retrospective study; SLE = systemic lupus erythematosus; sSS = secondary Sjögren's syndrome; UC = ulcerative colitis.