Table 1. | Primary Immune Regulatory Disorders (PIRD) framework |
| Component | Description |
|---|---|
| Population (P) | Patients with various types of oral lesions, including but not limited to premalignant, malignant and inflammatory/autoimmune conditions |
| Index test (I) | Immunofluorescence diagnostic testing |
| Reference test (R) | Conventional diagnostic methods such as clinical examination and histopathological analysis |
| Diagnosis/prognosis (D) | Diagnostic accuracy, sensitivity, specificity and clinical utility of immunofluorescence in the evaluation of oral lesions |
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