Study Year of
publication 		Study design Country Age Gender No. of
patients 		No. of
implants 		Implant location Definition of
peri-implantitis 		Peri-implantitis Mucositis
No (%) No (%)
Mayta-Tovalino et al. [22] 2019 Retrospective study Peru 53
(range 18 to 80) 		M: 213,
F: 218 		Total: 431,
osteoporosis: 12 		1279 Maxilla: 51%;
mandible: 49% 		NR Implants: 23 (2%) Implants: 23 (2%)
Dvorak et al. [30] 2011 Cross-sectional
study 		Austria 63 (SD 9) F: 177 Total: 177,
osteoporosis: 46,
osteopenia: 16 		828 Maxilla: 52%;
mandible: 48%;
anterior: 57%;
posterior: 43% 		BOP, suppuration, PD > 5 mm, RBL Patients: 110 (13%),
osteoporosis: 11 (24%),
osteopenia: 4 (25%) 		NS
Shabestari et al. [31] 2010 Retrospective case series Iran 53 (range 42 to 79) F: 21 Total: 21,
osteoporosis: 21 		Total: 46,
osteoporosis: 46 		Maxilla: 43%;
mandible: 57%;
anterior: 70%;
posterior: 30% 		NS Patients: 0 (0%),
osteoporosis: 0 (0%) 		Restarted their therapy after the osseointegration phase.
Seki et al. [32] 2023 Retrospective cohort study Japan 53.9 M: 34,
F: 55 		Total: 89,
osteoporosis: 4 		Total: 216,
osteoporosis: 16 		Maxilla: 52%;
mandible: 48% 		PD ≥ 6 mm, RBL ≥ 25%, suppuration Patients: 17 (19%).
Implants: 34 (16%),
osteoporosis: 15 (94%) 		NR
Renvert et al. [33] 2014 Retrospective study Sweden 56.5 M: 109,
F: 161 		Total: 270,
osteoporosis: 5 		NE NR RBL ≥ 2 mm, BOP,
suppuration, PD ≥ 4 mm 		Patients: 172 (64%),
osteoporosis: 4 (80%) 		Patients: 9 (3%), osteoporosis: 1 (20%)
Bell and Bell [34] 2008 Retrospective study USA NR M: 2,
F: 40 		Total: 42,
osteoporosis: 42 		Total: 101,
osteoporosis: 101 		NR NR NS NR
Astolfi et al. [35] 2022 Retrospective study Spain 47 (range 18 to 84) NR Total: 132,
osteoporosis: 11 		555 NR RBL Patients: 21 (16%),
osteoporosis: 3 (2%) 		NS
Suvarna et al. [36] 2016 Retrospective analysis India NR M: 30,
F: 82 		Total: 112,
osteoporosis: 112 		Total: 140,
osteoporosis: 140 		NS NR NS NR
Apaza-Bedoya et al. [37] 2024 Multicenter cross-sectional study Brazil 56 (range 31 to 77) M: 44,
F: 55 		Total: 99,
osteoporosis: 7 		Total: 266,
osteoporosis: 15 		NR BOP with or without suppuration, PD, RBL ≥ 3 mm Patients: 15 (15%),
implants: 31 (12%) 		Patients: 49 (50%),
implants: 114 (43%)
Romandini et al. [38] 2021 Cross-sectional
study 		Spain 63.7 M: 39,
F: 60 		99 458 Maxilla: 55%;
mandible: 45%;
anterior: 18%;
posterior: 82% 		PD, BOP, RBL ≥ 2 mm Patients: 31 (31%),
implants: 128 (28%) 		Patients: 1 (1%),
implants: 146 (32%)

M = male; F = female; NS = not specified; NR = not recorded; RBL = radiographic bone loss; PD = probing depth; BOP = bleeding on probing.