Author Year Materials Comments
Jiang et al. 2005 32 cell lines various cancers Cancer cells were clustered based on tissue of origin
Tran et al. 2007 9 cell lines HNOCC No controls. First study to provide a genome-wide survey of mature microRNA in head and neck
23 microRNAs up-regulated, among them let-7, microRNA-16, microRNA-21 and microRNA-205 (some known carcinogens)
22 microRNAs down-regulated
Chang et al. 2008 4 HNOCC cell lines, 4 tumour tissue samples and 4 normal tissue control 8 microRNAs up-regulated in cancer tissue versus control among them microRNA-21, microRNA-18, microRNA-19, microRNA-29c, microRNA-142, microRNA-3p, microRNA-155, microRNA-146b and let-7(some known to be involved in carcinogenesis)
1 microRNA down-regulated, microRNA-494
Wong et al. 2008 4 tumour tissue samples from OT cancer and 4 paired normal controls 24 microRNAs up-regulated among them microRNA-184 and microRNA-21 (known to be involved in carcinogenesis)
13 microRNAs down-regulated among them microRNA-100, microRNA-125, microRNA-133a and microRNA-133b
Kozaki et al. 2008 18 OSCC cancer cell lines, 11 primary frozen OSCC samples and immortalized keratinocyte line RT17 as control 11 microRNAs up-regulated among them microRNA-374, microRNA-340, microRNA-224, microRNA-31, microRNA-9 (some known to be involved in carcinogenesis)
54 microRNAs down-regulated among them micrRNA-137, microRNA-139a, mcroRNA-133b and microRNA-138
Avissar et al. 2009 16 fresh-frozen HNOCC tumours, 5 non diseased epithelial tissues and 2 HNOCC cell lines 11 microRNAs up-regulated among them microRNA-21 (known to be involved in carcinogenesis)
1 microRNA down-regulated, microRNA-375
Ramdas et al. 2009 5 tumour samples including OT and FOM and adjacent normal tissue as controls 16 microRNAs up-regulated including microRNA-21, microRNA-7, microRNA-34b, microRNA-155, microRNA-182, microRNA-15b, microRNA-185, let-7 (some known to be involved in carcinogenesis)
4 microRNAs down-regulated among them microRNA-23b, microRNA-125a, microRNA-125b
The study demonstrated potential for stratification of tumour versus adjacent normal tissue based on the differential expression of microRNA and their targeted genes
Scapoli et al. 2010 15 OSCC tumour samples (8 without known metastasis and 7 with nodal involvement) 13 microRNAs up-regulated among them microRNA-21 (known to be involved in carcinogenesis)
4 microRNAs down-regulated among them let-7i, microRNA-155 and microRNA-146a that were found to characterize disease progression – nodal metastasis
Lajer et al. 2011 51 OSCC and pharyngeal cancer samples and 40 controls 114 microRNAs deregulated between OSCC and normal control among them up-regulation of microRNA-31 and down-regulation of microRNA-375 were the most significant
38 microRNAs deregulated between pharyngeal cancers and normal
21 microRNAs deregulation were associated with HPV infection among them microRNA-127-3p and microRNA-363