MicroRNAs
deregulated
in HNOCC 		Proposed Target gene(s) additional mechanisms and findings Author / Year / Journal
microRNA-184 c-Myc Wong et al. / 2008 / Clin. Cancer Research.
micrRNA-133a
and
microRNA-133b 		PKM2 (pyruvate kinase type 2) Wong et al. / 2008 / Int. J. Cancer.
microRNA-137
and
microRNA-193a 		CDK6 (cyclin dependant kinase 6) Kozaki et al. / 2008 / Cancer Research.
E2F transcription factor 6 Additionally it was demonstrated that these two microRNAs are tumour suppressors epigenetically silenced during oral carcinogenesis through DNA hypermethylation
microRNA-15a Cyclin E PKCa (protien kinase c alpha) down regulates microRNA-15a that directly inhibits cyclin E Cohen et al /2009 / Cancer Research
microRNA-21 TPM1 and PTEN (tropomyosin 1 and phosphatase tensin) Most likely actual role of microRNA-21 in tumorigenesis is accomplished by complex interactions with tumour / metastasis and suppressor genes Zhu et al. / 2007 / Biol. Chem. Li et al. / 2008 / Clin. Cancer Research. Chang et al. / 2008 / J. Dent. Res.
microRNA-103
and
microRNA-107 		PDCD4 (programmed cell death protein 4) Ramdas et al. / 2008 / Head and Neck.
TGFBR3 (tumour growth factor receptor beta 3)
microRNA-205
and
let-7 		DHFR (dihydrofolate reductase) Nakashima et al. / 2008 / Acta Otolar.
let-7 has been associated in oral cancers with decreased survival in cases with the KRAS-LCS6 genotype variant Christensen et al. / 2009 / Carcinogenesis.
microRNA-125b
and
microRNA-100 		KLF13, CXCL11 and FOXA1 andEGFR3 (epidermoid growth factor receptor 3) Henson et al. / 2009 / Genes Chromosomes Cancer.
microRNA-222 MMP1 (matrix metalloproteinase 1) Liu et al / 2009 / Cancer Genom. Proteom.
SOD2 (manganese superoxide dismutase 2)
microRNA-24 DND1 (dead end 1, an RNA binding protein which in turn regulates a group of downstream genes at post-transcriptional levels) Liu et al. / 2009/ FEBS letters.
microRNA-7 IGF1R (insulin-like growth factor1 receptor) Jiang et al. / 2010 / Biochemical Journal.
microRNA-138 GNAI2 (G protein alpha inhibiting activity polypeptide 2) Jiang et al. / 2010 / International J. of Cancer.