First author | IV bisphosphonate use | ||||
---|---|---|---|---|---|
BP used | Mean duration of
BP use (years) |
Range of duration of
use of BP (years) |
Mean cumulative
dose of BP |
Range of cumulative
dose of BP |
|
Maines | Neridronate | 6.8 | 1 - 12.9 | 1679 mg | 144 - 5307 mg |
Brown | Zoledronate and/or Pamidronate | 6.5 | X | x | 29.4 - 1188 mg |
Malmgren | Pamidronate | 4.5 | 0.5 - 12.5 | x | 10 – 40 mg/m2 over 5 - 8 hours |
Chahine | Pamidronate | 4.6 | 0.3 - 9 | 40 mg/kg | 2.5 - 81 mg/kg |
Schwartz | Pamidronate | 4.6 | 0 - 21.9 | x | X |
BP = bisphosphonates; X - data not stated in published study. |