First author IV bisphosphonate use
BP used Mean duration of
BP use (years)
Range of duration of
use of BP (years)
Mean cumulative
dose of BP
Range of cumulative
dose of BP
Maines Neridronate 6.8 1 - 12.9 1679 mg 144 - 5307 mg
Brown Zoledronate and/or Pamidronate 6.5 X x 29.4 - 1188 mg
Malmgren Pamidronate 4.5 0.5 - 12.5 x 10 – 40 mg/m2 over 5 - 8 hours
Chahine Pamidronate 4.6 0.3 - 9 40 mg/kg 2.5 - 81 mg/kg
Schwartz Pamidronate 4.6 0 - 21.9 x X

BP = bisphosphonates; X - data not stated in published study.