Parameters Category NM OSF OSF + OSCC P-value
N (%) N (%) N (%)
Percentage
positivity
0 = no positive cells 1 (10) 10 (33.3) 21 (70) < 0.001a
1 = 0 to 25% 4 (40) 20 (66.6) 9 (30)
2 = 26 to 50% 5 (50) - -
3 = > 50% - - -
Pattern Absent 1 (10) 10 (33.3) 21 (70) 0.001a
Cytoplasm - - -
Nuclear 9 (90) 20 (66.6) 9 (30)
Layers 0 = absent 1 (10) 10 (33.3) - 0.233
1 = basal/parabasal 9 (90) 20 (66.6) -
2 = spinous - - -
3 = superficial layer - - -

Comparison of IHC expression of PTEN among groups using Pearson's Chi-square and Fisher exact test
aStatistically significant at level P < 0.05, Pearson's Chi-square and at level P < 0.05, Fischer exact test.
NM = normal mucosa; OSF = oral submucous fibrosis; OSCC = oral squamous cell carcinoma; N = number; IHC = immunohistochemical; PTEN = phosphatase and tensin homologue.