Study Year of
publication 		Study
design 		Patients
(n) 		Age
(years) 		Gender
Total Test Control Test Control Test Control
Mean (SD) Mean (SD)
De Angelis et al. [21] 2020 Prospective clinical trial 34 17 17 NR NR NR NR
Cosyn et al. [22] 2021 Randomized controlled trial 60 30 30 48.2 (16.3) 50.1 (17) 14 males
16 females 		15 males
15 females
Puisys et al. [23] 2021 Randomized controlled trial 45 23 22 41.6 (7.66) 39.8 (8.56) 11 males
12 females 		9 males
13 females
Thoma et al. [24] 2022 Randomized controlled trial 20 10 10 44.1 (12.8) 43.4 (18.7) 3 Males
7 females 		4 Males
6 females
De Angelis et al. [25] 2023 Prospective clinical trial 48 24 24 NR NR 13 males
11 females 		13 males
11 females
Ashurko et al. [26] 2025 Randomized controlled trial 32 16 16 41.94 (9.62) 37.19 (7.13) 3 males
13 females 		6 males
10 females

NR = not recorded.