Study No. of implants placed Follow-up
(months) 		Type of implant Type of graft Implant site of placement Marginal bone loss
(mm) 		Mid-buccal recession
(mm) 		Soft tissue thickness gain
(mm) 		PES
(1-14)
Test Control Test Control Test Control P-value Test Control P-value Test Control P-value Test Control P-value
Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD)
De Angelis et al. [21] 34 12 Bone level taped Bone level taped Porcine-derived collagen matrix SCTG from palate Maxilla/
mandible 		NR NR NR NR NR NR Occlusal: 0.68 (0.15);
buccal: 1.16 (0.25) 		Occlusal: 0.9 (0.16);
buccal: 1.35 (0.34) 		Occlusal:
< 0.0008;
buccal:
0.136 		8 (0.94) 8.29 (0.92) > 0.05
Cosyn et al. [22] 60 3 Nobel Biocare® Nobel Biocare® Cross-linked porcine collagen matrix SCTG from palate Anterior maxilla 0.72 0.34 0.001 0.91 0.16 < 0.001 0.85 1.15 0.054 10.59 10.47 ˃ 0.05
Puisys et al. [23] 45 12 Straumann® BLX™ Straumann® BLX™ Porcine collagen matrix SCTG from tuber area Anterior maxilla Mesial:
0.1 (0.21);
distal:
0.2 (0.26) 		Mesial:
0.2 (0.22);
distal:
0.2 (0.17) 		Mesial:
0.035;
distal:
1.000 		NR NR NR NR NR NR 12.1 (1.39) 12.9 (1.27) > 0.05
Thoma et al. [24] 20 60 NR NR Volume-stable collagen matrix SCTG from palate NR 0.5 (0.7) 0.4 (0.4) 0.772 NR NR NR 0.3 (1.1) 0.5 (1) 0.752 10.3 (2.6) 10.1 (2.6) > 0.05
De Angelis et al. [25] 48 12 MIS® or Straumann® MIS® or Straumann® Porcine-derived collagen SCTG from palate Maxilla/
mandible 		0.53 (0.35) 0.47 (0.36) 0.419 0.81 (0.35) 0.56 (0.4) 0.021 Buccal:
0.66 (0.31) 		Buccal:
1.16 (0.41) 		< 0.001 7.8 (0.96) 8.15 (1.86) > 0.05
Ashurko et al. [26] 32 6 Astra Tech Implant System™ Astra Tech Implant System™ Volume-stable collagen matrix SCTG from tuber area Posterior mandible NR NR NR NR NR NR 1.11 (0.44) 1.43 (0.81) NR 9.17 11.86 NR

NR = not recorded; PES = pink aesthetic score; SCTG = subepithelial connective tissue graft.