Study Study design Follow-up
(month) 		Number of patients Age
(years) 		Gender
Total Test Control Test Control Test Control
Mean (SD) Mean (SD) Male Female Male Female
Eshkol-Yogev et al. [16] Randomized
controlled trial 		3 32 17 15 50 (12.8)
(range 28 to 79) 		50 (16)
(range 28 to 78) 		7 10 8 7
Li Manni et al. [17] Randomized
controlled trial 		12 34 17 17 46.8 (11.3) 45.7 (10.4) 5 12 5 12
Tokuc and Kan [18] Randomized
controlled trial 		12 20 20 20 60.8 (6.4) 60.8 (6.4) 8 12 8 12
Hurtgen et al.* [19] Randomized
controlled trial 		36 26 13 13 46.8 (11.3) 45.7 (10.4) NR NR NR NR
Randomized
controlled trial 		60 25 11 14 46.8 (11.3) 45.7 (10.4) NR NR NR NR
Tokuc and Kan [20] Cohort
study 		60 19 19 19 64.8 (6.1) 64.8 (6.1) 7 12 7 12

SD = standard deviation; NR = not recorded; test = MIS® V3; control = MIS® C1.
*Hurtgen et al. [19] is a follow-up study of Li Manni et al. [17] with follow-up periods of 36 and 60 months.