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2016 Jul-Sep; Vol 7, No 3:e9 |
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e9 |
Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review J Oral Maxillofac Res 2016;7(3):e9 doi:10.5037/jomr.2016.7309 |
Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review
1Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.
2Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, USA.
Corresponding Author:
Department of Periodontics, College of Dentistry
University of Illinois at Chicago
801 S Paulina Street, Room 469G, Chicago, IL 60612
USA
Phone: +1-312-996-0265
E-mail: ttozum@uic.edu
ABSTRACT
Objectives: To review the current understanding of the biomarkers and enzymes associated with different forms peri-implant diseases and how their level changes influence the pathogenesis of the inflammatory diseases around dental implants.
Material and Methods: An electronic search in two different databases was performed including MEDLINE (PubMed) and EMBASE between 1996 to 2016. Human studies analyse peri-implant crevicular fluid (PICF) biomarker and enzyme levels of implants having peri-implant mucositis and peri-implantitis published in English language, were evaluated. A systematic review was performed to assess which biomarkers and enzymes in PICF were used to identify the inflammatory conditions around dental implants.
Results: Fifty-one articles were identified of which 41 were further evaluated and included in the analysis. Due to significant heterogeneity between included studies, a meta-analysis could not be performed. Instead, a systematic descriptive review was performed.
Conclusions: Biomarkers and enzymes in peri-implant crevicular fluid have shown promising results in differentiating from peri-implant disease condition to health. However, due to inconsistent results and acquiring much evidence from cross-sectional studies, additional evidence supported by randomized-controlled trials is needed to validate the links reported.
J Oral Maxillofac Res 2016;7(3):e9
doi: 10.5037/jomr.2016.7309
Accepted for publication: 19 August 2016
Keywords: biomarkers; dental implants; diagnosis; enzymes; inflammation.
To cite this article: Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review J Oral Maxillofac Res 2016;7(3):e9 URL: http://www.ejomr.org/JOMR/archives/2016/3/e9/v7n3e9ht.htm |
Received: 25 July 2016 | Accepted: 19 August 2016 | Published: 9 September 2016
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2016.