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MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas J Oral Maxillofac Res 2013 (Jan-Mar);4(1):e2 doi:10.5037/jomr.2013.4102 |
MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas
1Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, USA.
2Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
3Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
4Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, USA.
5Section of Nuclear Medicine, Department of Radiology, University of Illinois at Chicago, Chicago, Illinois, USA.
6Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, USA.
7UIC Cancer Center, Graduate College, University of Illinois at Chicago, Chicago, Illinois, USA.
Corresponding author:
College of Dentistry, University of Illinois at Chicago
801 South Paulina Street, Chicago, IL 60612
USA
Phone: 312-355-0825
Fax: 312-413-1604
E-mail: xfzhou@uic.edu
ABSTRACT
Objectives: Head and neck/oral cancer, predominantly head and neck squamous cell carcinoma (HNSCC), is the sixth most common cancer in the world. While substantial advances have been made to define the genomic alterations associated with head and neck/oral cancer, most studies are focused on protein coding genes. The aim of this article is to review the current literature on identified genomic aberrations of non-coding genes (e.g., microRNA) in head and neck/oral cancer (HNOC), and their contribution to the initiation and progression of HNOC.
Material and Methods: A comprehensive review of the available literature relevant to microRNA deregulation in HNSCC/HNOC, was undertaken using PubMed, Medline, Scholar Google and Scopus. Keywords for the search were: microRNA and oral cancer, microRNA and squamous cell carcinoma, microRNA deregulation and oral cancer, microRNA and carcinogenesis in the head and neck/oral cavity. Only full length articles in the English language were included.
Results: We recently identified a panel of microRNA deregulations that were consistently observed in HNSCC [Chen et al., Oral Oncol. 2012;48(8):686-91], including 7 consistently up-regulated microRNAs (miR-21, miR-7, miR-155, miR-130b, miR-223, miR-34b), and 4 consistently down-regulated microRNAs (miR-100, miR-99a, miR-125b, miR-375). In this review, we will first provide an overview on microRNA and HNSCC. We will then provide a comprehensive review on the roles of microRNA deregulations in HNSCC. The functional significance of the identified HNSCC-associated microRNAs and a number of other relevant microRNAs (e.g., miR-138, miR-98, miR-137, miR-193a and miR-218) will be discussed in detail.
Conclusions: Based on current literature, microRNA deregulation plays a major role in head and neck/oral cancer.
J Oral Maxillofac Res 2013 (Jan-Mar);4(1):e2
doi:10.5037/jomr.2013.4102
Accepted for publication: 4 March 2013
Keywords: squamous cell carcinoma of the head and neck; microRNA; carcinogenesis tests.
To cite this article: MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas. J Oral Maxillofac Res 2013;4(1):e2 URL: http://www.ejomr.org/JOMR/archives/2013/1/e2/v4n1e2ht.htm |
Received: 2 November 2012 | Accepted: 4 March 2013 | Published: 1 April 2013
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2013.