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A Comparative Clinical Evaluation of the Effect of Preoperative and Postoperative Antimicrobial Therapy on Postoperative Sequelae after Impacted Mandibular Third Molar Extraction J Oral Maxillofac Res 2014 (Apr-Jun);5(2):e2 doi:10.5037/jomr.2014.5202 |
A Comparative Clinical Evaluation of the Effect of Preoperative and Postoperative Antimicrobial Therapy on Postoperative Sequelae after Impacted Mandibular Third Molar Extraction
1Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Nigeria.
Corresponding Author:
Department of Oral and Maxillofacial Surgery, College of Medicine
University of Lagos
Nigeria
E-mail: clemoji2000@yahoo.co.uk
ABSTRACT
Objectives: To compare the effect of preoperative and postoperative antibiotics therapy on postoperative sequelae after impacted mandibular third molar extractions.
Material and Methods: This was a prospective study conducted at Department of Oral and Maxillofacial Surgery of the Lagos University Teaching Hospitalon consecutive patients with impacted third molar extractions for a 12 month period. Group I (n = 31) had administration of 1 gram of oral metronidazole and 1 gram of amoxicillin capsules 30 minutes preoperative and Group II (n = 31) had 500 milligrams of amoxicillin capsule 8 hourly and 400 milligrams of metronidazole tablets administered post operatively for 5 days. Pain, facial swelling and mouth opening assessment were done postoperatively and on days 1, 3 and 7.
Results: The general pattern of postoperative pain, regardless of antimicrobial use revealed that pain increased from day 1 to day 3 postoperatively and began to decrease in intensity subsequently up to the seventh day. There was however a statistically significant difference (P = 0.0001) between the two groups on the 7th postoperative day with the subjects in Group I showing lower pain intensity. The mean difference of the facial width on days 1 and 3 was significant (P = 0.04 and P = 0.0001 respectively) with subjects in Group II having a reduced facial width compared to those in Group I.
Conclusions: This study suggested that the administration of preoperative or postoperative antibiotics showed no marked differences in the degree of postoperative sequaele that occur after impacted mandibular third molar extractions.
J Oral Maxillofac Res 2014 (Apr-Jun);5(2):e2
doi:10.5037/jomr.2014.5202
Accepted for publication: 30 December 2013
Keywords: clinical research; drug therapy; sequelae; third molar; tooth impacted.
To cite this article: A Comparative Clinical Evaluation of the Effect of Preoperative and Postoperative Antimicrobial Therapy on Postoperative Sequelae after Impacted Mandibular Third Molar Extraction. J Oral Maxillofac Res 2014;5(2):e2 URL: http://www.ejomr.org/JOMR/archives/2014/2/e2/v5n2e2ht.htm |
Received: 13 November 2013 | Accepted: 30 December 2013 | Published: 1 July 2014
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2014.