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2015 Apr-Jun; Vol 6, No 2:e3 |
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e3 |
Cyclooxygenase-2 and Ki67 Expression in Oral Leukoplakia: a Clinicopathological Study J Oral Maxillofac Res 2015;6(2):e3 doi:10.5037/jomr.2015.6203 |
Cyclooxygenase-2 and Ki67 Expression in Oral Leukoplakia: a Clinicopathological Study
1Oral Diagnosis Clinic, Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Kocaeli University, Kocaeli, Turkey.
2Department of Tumour Pathology, Institute of Oncology, Istanbul University, Istanbul, Turkey.
Corresponding Author:
Oral Diagnosis Clinic, Department of Oral and Maxillofacial Radiology
Faculty of Dentistry, Kocaeli University
Yuvacik Yerleskesi, Basiskele, Kocaeli
Turkey
Phone: 00 90 2623442222
Fax: 00 90 2623442109
E-mail: alper.sinanoglu@kocaeli.edu.tr / alpersinanoglu@yahoo.com
ABSTRACT
Objectives: Oral leukoplakia is a precancerous lesion of the oral mucosa. The upregulation of Ki67 and cyclooxygenase-2 has been reported in both dysplastic and non-dysplastic tissues. The aim of this clinicopathological study was to investigate the prognostic value of Ki67 and cyclooxygenase-2 expression for oral leukoplakia.
Material and Methods: A total of 50 samples were investigated and the study group consisted of 30 oral leukoplakia samples. Samples of 10 intact oral mucosa and 10 squamous cell carcinoma were included as negative and positive control groups, respectively. Epithelial dysplasia was defined as oral intraepithelial neoplasia (OIN) and classified into subgroups 1 - 3. Tissue samples were assessed immunohistochemically for Ki67 and cyclooxygenase-2 expression. Clinicopathological correlations of oral leukoplakia patients were also investigated.
Results: All OIN 3 patients were non-smokers (P < 0.05), and homogeneous oral leukoplakia lesions also presented OIN. Both cyclooxygenase-2 and Ki67 expression increased with the severity of lesions, which defined different subgroups (P < 0.05), except there was no significant difference between the hyperkeratosis and OIN groups for Ki67 expression.
Conclusions: Cyclooxygenase-2 and Ki67 expression may have a prognostic value for the malignant transformation of oral leukoplakia.
J Oral Maxillofac Res 2015;6(2):e3
doi: 10.5037/jomr.2015.6203
Accepted for publication: 10 June 2015
Keywords: Cyclooxygenase 2; Ki-67 Antigen; leukoplakia; precancerous conditions.
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To cite this article: Cyclooxygenase-2 and Ki67 Expression in Oral Leukoplakia: a Clinicopathological Study. J Oral Maxillofac Res 2015;6(2):e3 URL: http://www.ejomr.org/JOMR/archives/2015/2/e3/v6n2e3ht.htm |
Received: 9 February 2015 | Accepted: 10 June 2015 | Published: 30 June 2015
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2015.