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2017 Jan-Mar; Vol 8, No 1:e3 |
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In Vitro Comparison of Biological Effects of Coe-Pak and Reso-Pac Periodontal Dressings J Oral Maxillofac Res 2017;8(1):e3 doi:10.5037/jomr.2017.8103 |
In Vitro Comparison of Biological Effects of Coe-Pak and Reso-Pac Periodontal Dressings
1Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2Department of Periodontics, School of Dentistry, Sabzevar University of Medical Sciences, Sabzevar, Iran.
3Department of Dental Biomaterials, School of Dentistry, Shahid Beheshti University of Medical sciences, Tehran, Iran.
Corresponding Author:
Department of Periodontics, Dental School
Sabzevar University of Medical Sciences, Sabzevar
Iran
Phone: +98 5144011300-6
Fax: +98 5144011300-6
E-mail: za_baghani@yahoo.com
ABSTRACT
Objectives: The purpose of the present study was to compare the cytotoxicity of Reso-Pac and Coe-Pak periodontal dressing.
Material and Methods: According to ISO-10993-12:2012, 1-, 3- and 7-day extracts of the two periodontal dressings were prepared in cell culture medium and exposed to the two cultured cell lines. Cell viability and proliferation at 24 h and 72 h following exposure were evaluated using quantitative MTT assay.
Results: The results showed a significant (P < 0.05) reduction in the viability of cells exposed to the 3- and 7-day Coe-Pak extracts at 24 h and 72 h compared to the control group (no exposure to the extract). Reso-Pac extracts slightly decreased cell viability compared to the control group. Understudy materials showed greater cytotoxicity against human osteoblast-like compared to the human gingival fibroblast cells. No significant (P > 0.05) difference was found in the viability of cells exposed to undiluted (100%) one-day extract and diluted (50%) extract of both understudy materials at 24 h and 72 h after exposure.
Conclusions: Based on the results, Reso-Pac periodontal dressing has less cytotoxicity than Coe-Pak.
J Oral Maxillofac Res 2017;8(1):e3
doi: 10.5037/jomr.2017.8103
Accepted for publication: 31 March 2017
Keywords: fibroblasts; materials testing; osteoblasts; periodontal dressings.
To cite this article: Kadkhodazadeh M, Baghani Z, Torshabi M, Basirat B. In Vitro Comparison of Biological Effects of Coe-Pak and Reso-Pac Periodontal Dressings J Oral Maxillofac Res 2017;8(1):e3 URL: http://www.ejomr.org/JOMR/archives/2017/1/e3/v8n1e3.pdf |
Received: 6 January 2017 | Accepted: 29 March 2017 | Published: 31 March 2017
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2017.