« Prev

2018 Oct-Dec; Vol 9, No 4:e4

Next »

---

e4

Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats Ricardo Basto Souza, Francisco Isaac Fernandes Gomes, Karuza Maria Alves Pereira, Paula Goes Pinheiro Dutra, Rodrigo Maranguape Silva da Cunha, Hellíada Vasconcelos Chaves, Mirna Marques Bezerra J Oral Maxillofac Res 2018;9(4):e4 doi:10.5037/jomr.2018.9404 Abstract | HTML | PDF | XML

---

Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats

Ricardo Basto Souza¹, Francisco Isaac Fernandes Gomes², Karuza Maria Alves Pereira³, Paula Goes Pinheiro Dutra³, Rodrigo Maranguape Silva da Cunha⁴, Hellíada Vasconcelos Chaves², Mirna Marques Bezerra¹

¹Faculty of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.

²Faculty of Dentistry, Federal University of Ceará, Sobral, Ceará, Brazil.

³Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.

⁴Biotechnology Research Group, Federal University of Ceará and Acaraú Valley State University, Sobral, Ceará, Brazil.

Corresponding Author:

Mirna Marques Bezerra

Faculty of Medicine, Federal University of Ceará-Campus Sobral

62-042-280, Avenida Comandante Maurocélio Rocha Ponte, 100, Derby, Sobral-CE

Brazil

Phone: 55 88-3611-2202

Fax: 55 88-3611-8000

E-mail: mirnabrayner@gmail.com

ABSTRACT

Objectives: The purpose of this study was to determine the effects of strontium ranelate on ligature-induced periodontitis in rats and assess the putative involvement of heme oxygenase-1 (HO-1) pathway in these effects.

Material and Methods: Male Wistar rats underwent nylon ligature placement around maxillary molars and were treated (v.o.) with strontium ranelate (20 or 100 mg/kg) for 7 days. After that, rats were euthanized and histomorphometric/histopathological analyses and RT-PCR for HO-1 expression were performed.

Results: Strontium ranelate (20 or 100 mg/kg) prevented bone resorption by 28% and 38%, respectively. Strontium ranelate treatment (100 mg/kg) up-regulated (P < 0.05) heme oxygenase-1 mRNA levels in the gingival tissues in comparison to control groups.

Conclusions: Strontium ranelate prevented periodontal bone loss in experimental periodontitis in rats while heme oxygenase-1 mRNA levels increased after treatment.

J Oral Maxillofac Res 2018;9(4):e4

doi: 10.5037/jomr.2018.9404

Accepted for publication: 27 December 2018

Keywords: bone resorption; diphosphonates; heme oxygenase; periodontitis.

---

To cite this article: Souza RB, Gomes FIF, Pereira KMA, Dutra PGP, da Cunha RM, Chaves HV, Bezerra MM. Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats J Oral Maxillofac Res 2018;9(4):e4 URL: http://www.ejomr.org/JOMR/archives/2018/4/e4/v9n4e4ht.htm doi: 10.5037/jomr.2018.9404

Received: 15 November 2018 | Accepted: 27 December 2018 | Published: 30 December 2018

---

Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2018.