Study Year of publication Study design Allowed healing time
(months) 		N patients
(group 1/group 2) 		N sockets (group 1/group 2) Inclusion of molar teeth? Bone substitute materials used Type of bone substitutes Barrier membrane used Flap/primary closure Setting Country Method of measurement
Aimetti et al. [22] 2009 Parallel 3 22/18 22/18 No MGCSH/nothing Alloplast None No/no University Italy Clinical
Azizi and Moghaddam [23] 2009 Parallel 6 15/15 15/15 NR DBBM/nothing Xenograft Collagen
/none 		Yes/yes University
and private practice 		Iran Clinical
Barone et al. [24] 2008 Parallel 7 20/20 20/20 No CCPB/nothing Xenograft Collagen
/none 		Yes/yes University Italy Clinical
Barone et al. [25] 2014 Parallel 3 30/29 32/32 Yes CCPB Xenograft Collagen No/no University
and private practice 		Italy Clinical
Borg et al. [26] 2015 Parallel 5 20/20 20/20 No 100% FDBA
/70% cortical mineralized and 30% cortical 		Allograft d-PTFE Yes/yes University USA Clinical
Brownfield and Weltman [27] 2012 Parallel 3 17 (total) 10/10 No DBM with cancellous bone chips/nothing Allograft/nothing None No/no University USA CBCT
Cardaropoli et al. [28] 2014 Parallel 4 41 (total) 24/24 Yes DBBM blended with collagen/nothing Xenograft/nothing Collagen/none No/no Private practice Italy Clinical
Cook and Mealey [29] 2013 Parallel 5 22 23 No 90% inorganic bovine + 10% porcine collagen fibers Xenograft Collagen Yes/yes University USA Clinical
Eskow and Mealey [30] 2014 Parallel 5 32 (total) 15/17 No FDBA CO/FDBA CA Allograft/allograft Collagen
(if dehiscence) 		No University USA Clinical
Fotek et al. [31] 2009 Parallel 4 8/10 8/10 No Solvent-preserved mineralized cancellous allograft Allograft ADM/d-PTFE No University USA Clinical
Hoang et al. [32] 2012 Parallel 4 and 5 16/14 16/14 Yes DBM putty with one size of bone particles/DBM putty with two different sizes of bone particles Allograft/allograft Collagen membrane
(if dehiscence) 		Flap was reflected only if a significant bony dehiscence was detected University USA Clinical
Iasella et al. [33] 2003 Parallel 4 or 6 12/12 12/12 No Tetracycline hydrated FDBA
/nothing 		Allograft/nothing Collagen/none Yes/yes University USA Clinical
Iorio-Siciliano et al. [34] 2017 Parallel 6 10/10 10/10 N/R Bovine-derived xenograft collagen/nothing Xenograft/nothing Collagen/none Yes/yes University Italy Clinical
Jung et al. [35] 2013 Parallel 6 10/10/10/10 10/10/10/10 No B-TCP/DBBM-C/DBBM-C/nothing Alloplast/xenograft/xenograft/nothing None/collagen/none/none No University Switzerland CBCT
Jung et al. [36] 2018 Split- mouth 6 18 18/18 Yes DBBM-C/nothing Xenograft/nothing Collagen/none No University China CBCT
Lim et al. [37] 2017 Parallel 4 26 26 No Collagenated bovine bone Xenograft Collagen Yes University Korea CBCT
Mardas et al. [38] 2010 Parallel 8 13/14 13/14 No DBBM/bone ceramic Xenograft/alloplast Collagen Yes/yes University England Clinical
Meloni et al. [39] 2015 Parallel 5 15/15 15/15 No DBBM Xenograft None No Private practice Italy, Spain CBCT
Nart et al. [40] 2017 Parallel 5 21 (total) 11/11 No DBBM/DBBM-C Xenograft/xenograft Collagen No University Spain CBCT
Natto et al. [41] 2017 Parallel 4 14/14 14/14 No FDBA and collagen matrix seal/FDBA and collagen sponge Allograft/allograft None No University USA CBCT
Pang et al. [42] 2014 Parallel 6 15/15 15/15 Yes DBBM/nothing Xenograft
/nothing 		Collagen/none Yes/NR University China CBCT
Park et al. [43] 2016 Parallel 4 14 14 Yes Demineralized bovine bone matrix mixed with 10% collagen Xenograft Collagen No University Korea CBCT
Parashis et al. [44] 2016 Parallel 4 23 23 No FDBA Allograft Collagen No University USA Clinical
Poulias et al. [45] 2013 Parallel 4 12 12 No Mineralized, CA, particulate Allograft Polylactide Yes/yes University USA Clinical
Sadeghi et al. [46] 2016 Parallel 4 - 6 10/10 10/10 No DFDBA/DBBM Allograft/xenograft Collagen Yes University Iran Clinical
Toloue et al. [47] 2012 Parallel 3 12 13 No Calcium sulfate Alloplast None No University USA Clinical
Vance et al. [48] 2004 Parallel 4 12 12 No DBBM Xenograft Collagen Yes University USA Clinical
Whetman et al. [49] 2016 Parallel 2 - 2.5
or 4.5 - 5 		22/19 22/19 No DFDBA Allograft Collagen
(if dehiscence) 		Yes University USA Clinical
Wood and Mealey [50] 2012 Parallel 5 16/16 16/16 No DFDBA/FDBA Allograft/allograft Collagen No University USA Clinical
Serrano Mendez [51] 2017 Parallel 6 10/10 10/10 No DFDBA/DBBM Allograft/xenograft Collagen Yes/yes University Columbia Clinical
Fernandes et al. [52] 2016 Split-mouth 6 - 8 16 16 No Mineralized bone graft Allograft ADM No University Brazil NR
Fernandes et al. [53] 2011 Split-mouth 6 18 18 No Anorganic bone matrix with synthetic cell-binding peptide P-15 Alloplast ADM No University Brazil Clinical
Festa et al. [54] 2013 Split-mouth 6 15/15 15/15 No CCPB/nothing Xenograft/nothing Soft cortical membrane/none Yes/yes University Italy Clinical
Gholami et al. [55] 2012 split-mouth 6.9 (SD 0.8) 12 14/14 No DBBM/nanocrystalline hydroxyapatite Xenograft/alloplast Collagen Yes/yes University Iran Clinical
Hassan et al. [56] 2017 Split-mouth 3 9 11/11 No Demineralized freeze-dried bone/mineralized freeze-dried bone Allograft/allograft Amnion-chorion/d-PTFE No/no University USA Clinical and CBCT
Temmerman et al. [57] 2016 Split-mouth 3 22 22 No Nothing Nothing None No University Belgium CBCT
Kotsakis et al. [58] 2014 Parallel 5 10/8/6 12/12/6 Yes Calcium phosphosilicate putty alloplast/bovine bone mineral/nothing Alloplast/xenograft/nothing None No University USA Clinical
Guarnieri et al. [59] 2017 Parallel 4 8/9 8/9 Yes Porcine-derived bone/nothing Xenograft/nothing Collagen/none No/no University Italy Clinical
Barone et al. [60] 2017 Parallel 3 30/30/30 30/30/30 Yes Collagenated CCPB/cortical porcine bone/nothing Xenograft/xenograft/nothing Collagen/collagen/none No/no/no University Italy, Spain Clinical
Demetter et al. [61] 2017 Parallel 5 58 (total) 19/19/20 No 100% cortical FDBA/100% CA/FDBA 50 - 50% cortico-cancellous FDBA Allograft/allograft/allograft d-PTFE No University USA Clinical

N = number, d-PTFE = dense polytetrafluoroethylene; MGCSH = medical-grade calcium sulfate hemihydrate; DBM = demineralized bone matrix; DBBM = deproteinized bovine bone mineral; DBBM-C = deproteinized bovine bone mineral with 10% collagen; CCPB = cortico-cancellous porcine bone; FDBA = freeze-dried bone allograft; NR = not reported; CBCT = cone-beam computed tomography.