Study Socket grafting materials Control group Systemic antibiotics No. of implants Time of implant placement Implant type Loading protocol Maintenance program
Tallarico et al. [27] Corticocancellous porcine bone (GENOSS, OsteoBiol®) + portice derma (OsteoBiol®) Immediate implants placed into the sockets grafted with corticocancellous porcine bone (GENOSS, OsteoBiol®) + portice derma (OsteoBiol®) Prophylactic preoperatively;
4 days postoperativelya 		24 implants.
Test: 12;
Control: 12 		4 months Osstem® 7 mm wide 4 months: definitive restorations -
Tallarico et al. [28] Corticocancellous porcine bone + extracellular resorbable membrane.
GENOSS, OsteoBiol® + portice derma (OsteoBiol®) 		Immediate implants placed into the sockets grafted with corticocancellous porcine bone (GENOSS, OsteoBiol®) + portice derma (OsteoBiol®) Prophylactic preoperatively;
4 days postoperativelya		 24 implants.
Test: 12;
Control: 12 		4 months Osstem® 7 mm wide 4 months: definitive restorations Recall visits every 6 months, up to 1 year.
Cardaropoli et al. [29] Deproteinized bovine bone graft (Geistlich Bio-Oss®) + absorbable collagen membrane (Geistlich Bio-Gide®) Implants placed in naturally healed sites No 48 implants.
Test: 24;
Control: 24 		4 months 4 to 5 mm diameter, conical shape. (Biomet/3i) 4 months NR
Barone et al. [30] Corticocancellous porcine bone particles (OsteoBiol®) + collagene membrane (OsteoBiol®) Implants placed in naturally healed sites Prophylactic preoperatively;
4 days postoperativelya		 40 implants.
Test: 20;
Control: 20 		4 months 3.3 to 5 mm diameter, 10 to 13 mm length (Sweden & Martina®) 4 months Oral hygiene every 3 months
Marconcini et al. [31] Test 1: Collagenated corticocancellous porcine bone particles (OsteoBiol®) + collagene membrane (OsteoBiol®)
Test 2: cortical porcine bone (OsteoBiol®) + collagene membrane (OsteoBiol®) 		Implants placed in naturally healed sites Prophylactic preoperatively;
4 days postoperativelya		 42 implants.
Test 1: 15;
Test 2: 14;
Control: 13 		3 months Diameter: NR;
BT Evo; Biotech 		Two-stage surgery
4 month 		Personalized maintenance programme and recall visits
Felice et al. [32] Algae-derived frios algipore (Dentsply Friadent®) + Geistlich Bio-Gide® Immediate implant placement
bone-to-implant gaps filled with algae-derived bone substitute 		Prophylactic preoperatively;
4 days postoperativelya		 50 implants.
Test: 25;
Control: 25 		4 months Diameter: 3.8/4.5/5.5 mm, length: 8/9.5/11/13/15 mm
Xive S plus, Dentsply® 		Immediate restoration
(> 35 N);
4 months (< 35 N);
4 months definitive crown 		Oral hygiene and recall visit every 6 months
Esposito et al. [33] Deproteinized bovine bone graft (Bio-Oss®) + absorbable collagen membrane (Geistlich Bio-Gide®) Immediate implant placement
35 implants (40%) bone-to-implant gaps were filled with anorganic bovine bone 		Prophylactic preoperatively;
4 days postoperativelya		 106 implants.
Test: 54;
Control: 52 		4 months Diameter: 4/5 mm
Length: 7/8.5/10/11.5/13/15 mm
(MegaGen®) 		Immediate restoration
(> 35 N);
4 months (< 35 N);
4 months definitive crown 		NR
Esposito et al. [34] Collagenated corticocancellous porcine bone particles (OsteoBiol®) + resorbable membrane derived from equine pericardium (OsteoBiol®) Control 1: immediate placed implants.
Control 2: immediate-delayed placed implants after 6 weeks post extraction 		Prophylactic preoperatively;
4 days postoperativelya		 210 implants.
Test: 70;
Control 1: 70
Control 2: 70 		4 months Diameter: 3.5/4.3/5 mm; length: 8.5/10/11.5/13/15 mm
(Nobel Biocare®) 		Two-stage surgery; Loading with prov. Crowns 4/6 months after surgery Oral hygiene and recall visit every 6 months

aProphylactic preoperatively 2 g amoxicillin or 600 mg clindamycin (in case of allergy); 4 days postoperatively 1 g amoxicillin or 300 mg clindamycin twice a day.