Study Implant survival
(%) 		Radiographic bone
assessment 		Clinical
parametersa		 Peri-implant diseases Aesthetic outcomesb Other findings
Tallarico et al. [27] Test: 100%;
Control: 100% 		MBL changes.
Test: 0.23 (SD 0.06) mm;
Control: 0.63 (SD 0.31) mm; P = 0.001 		NR NR PES score.
Test group: 12.2 (SD 1.2);
Control group: 10.6 (SD 1.8); P = 0.019 		-
Tallarico et al. [28] Test: 100%;
Control: 100% 		MBL changes.
Test: 0.23 (SD 0.06) mm;
Control: 0.63 (SD 0.31) mm; P = 0.01 		NR NR PES score.
Test group: 11.7 (SD 1.2);
Control group: 10.7 (SD 1.5); P = 0.081 		-
Cardaropoli et al. [29] Test: 100%;
Control: 100% 		MBL changes.
Test: 0.33 (SD 0.28) mm
Control: 0.35 (SD 0.27) mm; P = 0.8 		NR NR NR During implant placement additional bone grafting was necessary in 14 implants in Test group (58.33%), P < 0.05.
MBL > 1 mm during the first year:
Test: 1 implant;
Control: 2 implants (P = 0.98)
Barone et al. [30] Test: 95%;
Control: 95% 		MBL changes.
1 year:
Test: 0.75 (SD 0.3) mm;
Control: 0.76 (SD 0.3) mm; P = 0.82
2 years:
Test: 0.83 (SD 0.2) mm;
Control: 0.84 (SD 0.2) mm; P = 0.66
3 years:
Test: 1 (SD 0.2) mm;
Control: 1.02 (SD 0.3) mm; P = 0.52 		NR NR NR During implant placement additional bone grafting was necessary in 13 implants in the Test group and 10 in the Control group (P = 0.02)
Marconcini et al. [31] Test 1: 100%;
Test 2: 100%;
Control: 100% 		MBL changes.
Test 1: 1.14 (SD 0.23) mm;
Test 2: 1.13 (SD 0.29) mm;
Control: 1.95 (SD 0.07) mm.
Significantly higher in control group
( P < 0.001) 		NR NR PES score.
Test 1: 9.42 (SD 0.75);
Test 2: 8.53 (SD 1.18);
Control: 6.07 (SD 1.89).
Significantly higher in Test 1 compared to Test 2 and Control groups (P = 0.02) 		During implant placement additional bone grafting was necessary in 6 implants in the Control group
Felice et al. [32] Test: 100%;
Control: 92% 		MBL changes.
Test 0.19 (SD 0.1) mm;
Control 0.13 (SD 0.09) mm; P < 0.001 		NR NR PES score.
Test group: 12.22;
Control group: 12.78; P = 0.09 		-
Esposito et al. [33] Test: 100%;
Control: 96% 		MBL changes.
Test: 0.27 (SD 0.14) mm;
Control: 0.13 (SD 0.16) mm.
Significantly higher for the test implants (P < 0.036) 		NR NR PES score.
Test group 12.8 (SD 1.4);
Control group: 13 (SD 1.5); P = 0.615 		-
Esposito et al. [34] Test: 98%;
Control 1: 94%;
Control 2: 94% 		MBL loss.
Test: 0.31 (SD 0.16) mm;
Control 1: 0.25 (SD 0.17) mm;
Control 2: 0.29 (SD 0.14) mm.
Significantly higher for the test implants (P < 0.0001) 		NR NR PES score.
Test group: 11.78 (SD 1.1);
Control 1: 12.52 (SD 1.08);
Control 2: 12.49 (SD 0.96); P < 0.0001 		-

aClinical parameters: probing depth, bleeding on probing, mucosal recession.
bAesthetic outcomes: papilla index, PES (pink aesthetic score).
MBL = marginal-bone-level; PES = pink aesthetic score (mean value); SD = standard deviation; NR = not reported.