No.
|
Gene
|
Protein
|
Biological function
|
1.
|
ANXA1*
|
Annexin A1
|
This protein plays a role in cellular response to vascular endothelial growth factor stimulus.
|
2.
|
THBS1*
|
Thrombospondin-1
|
This protein induce blood vessel endothelial cell migration, has a positive regulation of fibroblast migration, positive regulation of angiogenesis, positive regulation of cell population proliferation.
|
3.
|
CALR*
|
Calreticulin
|
This protein has a positive regulation of endothelial cell migration.
|
4.
|
COL3A1*
|
Collagen alpha-1(III) chain
|
It acts in collagen fibril organization, wound healing, cell-matrix adhesion.
|
5.
|
HSPG2*
|
Basement membrane-specific heparan sulfate proteoglycan core protein
|
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization.
|
6.
|
FBN1*
|
Fibrillin-1
|
Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin.
|
7.
|
COL4A1*
|
Collagen alpha-1(IV) chain
|
Type IV collagen is the major structural component of glomerular basement membranes, forming a ‘chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen.
|
8.
|
SERPINE1*
|
Plasminogen activator inhibitor 1
|
It is required for stimulation of keratinocyte migration during cutaneous injury repair.
|
9.
|
CST3*
|
Cystatin-C
|
Cystatin acts as a regulator of tissue remodeling, has a negative sense to regulation of collagen catabolic process and regulation of blood vessel remodeling.
|
10.
|
DPP4*
|
Dipeptidyl peptidase 4
|
In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM.
|
11.
|
KRT1*
|
Keratin, type II cytoskeletal 1
|
This protein plays a role in keratinization and regulation of angiogenesis.
|
12.
|
CHI3L1*
|
Chitinase-3-like protein 1
|
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. Play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment.
|
13.
|
LRP1*
|
Prolow-density lipoprotein receptor-related protein 1
|
Act as an inducer of vascular associated smooth muscle cell migration.
|
14.
|
MMP2*
|
72 kDa type IV collagenase
|
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture.
|
15.
|
GPNMB*
|
Transmembrane glycoprotein NMB
|
It has a sense in regulation of angiogenesis, regulation of tissue remodeling.
|
16.
|
NRP1*
|
Neuropilin-1
|
Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system.
|
17.
|
SERPING1
|
Plasma protease C1 inhibitor
|
Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins.
|