No | Gene | Protein | Biological function |
---|---|---|---|
1. | CHI3L1* | Chitinase-3-like protein 1 | Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. |
2. | CD109* | CD109 antigen | Modulates negatively TGFB1 signaling in keratinocytes. |
3. | SERPINE1* |
Plasminogen activator inhibitor 1 |
This protein has a role in positive regulation of interleukin-8 production, positive regulation of monocyte chemotaxis, positive regulation of inflammatory response. |
4. | PSAP* | Prosaposin | This protein has a sense in regulation of autophagy, platelet degranulation, neutrophil degranulation. |
5. | ANXA2* | Annexin A2 | This annexin has a positive regulation of vacuole organization, positive regulation of vesicle fusion, vesicle budding from membrane. |
6. | ANXA5 | Annexin A5 | This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
7. | FTL | Ferritin light chain | Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. |
8. | FTH1 | Ferritin heavy chain | Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. |
9. | ANXA1* | Annexin A1 | Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. |
10. | ANXA4 | Annexin A4 | Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. |
11. | NHLRC3* |
NHL repeat-containing protein 3 |
This protein has a role in neutrophil degranulation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination. |
12. | LGALS3BP | Galectin-3-binding protein | Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumour cells. |
13. | DPP4* | Dipeptidyl peptidase 4 | Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. |
14. | PTX3 | Pentraxin-related protein PTX3 | Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. |
15. | HSPG2* |
Basement membrane-specific heparan sulfate proteoglycan core protein |
Endorepellin in an anti-angiogenic and anti-tumour peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. |
16. | KRT1* | Keratin, type II cytoskeletal 1 | May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. |
17. | GNS* | N-acetylglucosamine-6-sulfatase | This protein plays a role in glycosaminoglycan catabolic process, keratan sulfate catabolic process, neutrophil degranulation. |
18. | C1R | Complement C1r subcomponent | C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. |
19. | CALR* | Calreticulin | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. |
20. | CTSD* | Cathepsin D | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation |
21. | CTSS* | Cathepsin S | Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. |
22. | A2M* | Alpha-2-macroglobulin | This protein has a role in platelet degranulation, negative regulation of complement activation, lectin pathway. |
23. | C4A* | Complement C4-A | Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. |
24. | LAMP1* |
Lysosome-associated membrane glycoprotein 1 |
Presents carbohydrate ligands to selectins. Also implicated in tumour cell metastasis. Acts as a receptor for Lassa virus protein. |
25. | S100A11 | Protein S100-A11 | Facilitates the differentiation and the cornification of keratinocytes. |
26. | CTSB* | Cathepsin B | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. |
27. | PSMA6* |
Proteasome subunit alpha type-6 |
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. |
28. | PDIA3 | Protein disulfide-isomerase A3 | This protein plays a role in antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, positive regulation of extrinsic apoptotic signalling pathway. |
29. | SERPINB1 | Leukocyte elastase inhibitor | Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. |
30. | SERPINB6 | Serpin B6 | May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Inhibitor of cathepsin G, kallikrein-8 and thrombin. |
31. | LGALS3 | Galectin-3 | Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. |
32. | PSMA1* |
Proteasome subunit alpha type-1 |
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. |
33. | PRDX1* | Peroxiredoxin-1 | Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. |
34. | SERPINB2 |
Plasminogen activator inhibitor 2 |
Protein has a sense in interleukin-12-mediated signalling pathway, fibrinolysis, wound healing. |
35. | PPIA* | Peptidyl-prolyl cis-trans isomerase A | Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation. |
*Proteins cells are also involved in other biological processes. |