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Therapeutic Approach in the Treatment of Medication-Related Osteonecrosis of the Jaw: Case Series of 3 Patients and State of the Art on Surgical Strategies J Oral Maxillofac Res 2021;12(2):e6 doi:10.5037/jomr.2021.12206 Abstract | HTML | PDF | XML |
Therapeutic Approach in the Treatment of Medication-Related Osteonecrosis of the Jaw: Case Series of 3 Patients and State of the Art on Surgical Strategies
1Maxillofacial and Dental Surgical Unit, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
2Pathological Anatomy and Histopathology Unit, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Corresponding Author:
Maxillofacial and Dental Surgical Unit
Department of Medical, Surgical and Health Sciences
University of Trieste
Piazza dell’Ospitale 1, 34129, Trieste
Italy
Phone: +390403992020
Fax: +390403992022
E-mail: evettori@units.it
ABSTRACT
Background: Bisphosphonates and receptor activator of nuclear factor kappa-B ligand inhibitors are currently the most widely used antiresorptive therapies in bone metabolism diseases treatment. Unfortunately they can evoke medication-related osteonecrosis of the jaws. The present case series study proposes to evaluate clinical features, evolution and the surgical therapeutic approaches in three patients affected by medication-related osteonecrosis of the jaw and to review the state of art regarding the management of this complication in light of the most recent literature.
Methods: Three cases of medication-related osteonecrosis of the jaws are discussed, two related to bisphosphonates therapy (ibandronic acid) and one due to denosumab.
Results: All three patients were aged female and had probably a dental trigger agent. The lesions located in posterior mandible were treated in one case with the surgical approach alone and, in the other case, with surgical approach associated with Erb-YAG laser. The lesion related to denosumab was treated with surgical approach and platelet rich fibrin application. A complete healing was always achieved.
Conclusions: Dentists should be aware of the potential risk of developing medication-related osteonecrosis of the jaws for patients who take or had taken antiresorptive drugs. The side effects of denosumab and bisphosphonates are partly overlapping and currently there is still no consensus about the therapeutic surgical options. Prevention and early detection of the lesions should be the primary strategy.
J Oral Maxillofac Res 2021;12(2):e6
doi: 10.5037/jomr.2021.12206
Accepted for publication: 8 May 2021
Keywords: antiresorptive drugs; laser therapy; oral surgery; osteonecrosis; platelet-rich fibrin.
To cite this article: Therapeutic Approach in the Treatment of Medication-Related Osteonecrosis of the Jaw: Case Series of 3 Patients and State of the Art on Surgical Strategies J Oral Maxillofac Res 2021;12(2):e6 URL: http://www.ejomr.org/JOMR/archives/2021/2/e6/v12n2e6ht.htm |
Received: 26 January 2021 | Accepted: 8 May 2021 | Published: 30 June 2021
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2021.