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Effects of Systemic Propranolol Application on the New Bone Formation in Periimplant Guided Bone Regeneration J Oral Maxillofac Res 2021;12(3):e2 doi:10.5037/jomr.2021.12302 Abstract | HTML | PDF | XML |
Effects of Systemic Propranolol Application on the New Bone Formation in Periimplant Guided Bone Regeneration
1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Dicle University, Diyarbakir, Turkey.
2Department of Periodontology, Faculty of Dentistry, Harran University, Sanliurfa, Turkey.
3Department of Periodontology, Faculty of Dentistry, Firat University, Elazig, Turkey.
4Department of Pathology, Faculty of Medicine, Firat University, Elazig, Turkey.
5Department of Cardiology, Faculty of Medicine, Firat University, Elazig, Turkey.
6Department of Prosthodontics, Faculty of Dentistry, Firat University, Elazig, Turkey.
7Department of Prosthodontics, Goldman School of Dental Medicine, Boston University, Boston, USA.
Corresponding Author:
Department of Periodontology, Faculty of Dentistry
Hamidiye Mah. Harran Üniversitesi
Yenişehir Kampüsü, Haliliye, Şanlıurfa
Turkey
Phone: 05359255812
Fax: +90 414 318 31 90
E-mail: m.gul3838@gmail.com
ABSTRACT
Objectives: The aim of this experimental animal study was to evaluate the effects of systemic propranolol on new bone formation in peri-implant bone defects.
Material and Methods: Implant slots were created 4mm long and 2.5 mm wide. After the titanium implants were placed in the sockets, 2 mm defects were created in the neck of the implants. Bone grafts were placed in these defects. Then the rats were randomly divided into three equal groups: control (n = 8), propranolol dose-1 (PRP-1) (n = 8), and propranolol dose-2 (PRP-2) (n = 8) groups. In the control group, the rats received no further treatment during the eight-week experimental period after the surgery. The rats in the PRP-1 and PRP-2 groups were given 5 mg/kg and 10 mg/kg propranolol, respectively, every three days for the eight-week experimental period after the surgery. At the end of the experimental period, the rats were euthanized. Blood serum was collected for biochemical analysis, and the implants and surrounding bone tissues were used for the histological analysis.
Results: There were no significant differences in the histological analysis results and the biochemical parameters (alkaline phosphatase, calcium, creatinine and phosphorus) of the groups (P > 0.05). Also, in the test groups, there was numerically but not statistically more new bone formation detected compared with the controls.
Conclusions: Within the limitations of this study, propranolol did not affect the new bone formation in peri-implant defects.
J Oral Maxillofac Res 2021;12(3):e2
doi: 10.5037/jomr.2021.12302
Accepted for publication: 11 August 2021
Keywords: bone; peri-implantitis; propranolol; regeneration.
To cite this article: Effects of Systemic Propranolol Application on the New Bone Formation in Periimplant Guided Bone Regeneration J Oral Maxillofac Res 2021;12(3):e2 URL: http://www.ejomr.org/JOMR/archives/2021/3/e2/v12n3e2ht.htm |
Received: 20 April 2021 | Accepted: 11 August 2021 | Published: 30 September 2021
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2021.