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2021 Jul-Sep; Vol 12, No 3:e4 |
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Osseointegration Aspects of Implants at the Bone Reconstruction Site by a Novel Porous Titanium Scaffold J Oral Maxillofac Res 2021;12(3):e4 doi:10.5037/jomr.2021.12304 Abstract | HTML | PDF | XML |
Osseointegration Aspects of Implants at the Bone Reconstruction Site by a Novel Porous Titanium Scaffold
1Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Corresponding Author:
Department of Advanced Prosthodontics
Hiroshima University Graduate School of Biomedical and Health Sciences
1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553
Japan
Phone: +81 82 257 5677
Fax: +81 82 257 5679
E-mail: kazuya17@hiroshima-u.ac.jp
ABSTRACT
Objectives: Porous titanium is used for the reconstruction of large bone defects due to its excellent mechanical strength. The quality of osseointegration of implants placed in bone reconstructed with porous titanium is unknown. The purpose of this in vivo study was to evaluate the osseointegration of implants at sites reconstructed using porous titanium.
Material and Methods: Hollow porous titanium (Ti) (outer-diameter 6 mm, inner-diameter 2 mm, length 4 mm, 85% porosity) and similar-sized porous hydroxyapatite (porous HA: 75% porosity) samples were prepared and implanted in 6 New Zealand white rabbit femurs. Four weeks later, an implant bed was created to receive a Ti implant (diameter 2 mm, length 4 mm). An implant placed at a pristine bone site served as the control. Four weeks later, histological and histomorphometric evaluations of the test and control sites were conducted.
Results: Osseointegration was observed in all groups. There was no significant difference in the bone formation ratio and bone-implant contact (BIC) ratio across all groups for the whole area. At the cancellous bone area of the bone defect, superior bone formation ratio and BIC ratio were observed with porous Ti and porous HA compared to the control (bone formation ratio: control 1.8 [SD 3]%, HA 23 [SD 3]%, Ti 23.6 [SD 5]%; BIC ratio: control 5.4 [SD 5.3]%, HA 28.9 [SD 10.7]%, Ti 41.6 [SD 14]%). Porous Ti demonstrated good osteoconduction and osseointegration abilities, similar to porous HA.
Conclusions: To our knowledge, this is the first report of implant treatment after preliminary bone reconstruction using a titanium biomaterial. Porous titanium is a suitable material for bone reconstruction before implant treatment in load-bearing areas that allow subsequent prosthetic treatment.
J Oral Maxillofac Res 2021;12(3):e4
doi: 10.5037/jomr.2021.12304
Accepted for publication: 11 August 2021
Keywords: biocompatible material; dental implants; dental implantation; oseointegration; titanium.
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To cite this article: Osseointegration Aspects of Implants at the Bone Reconstruction Site by a Novel Porous Titanium Scaffold J Oral Maxillofac Res 2021;12(3):e4 URL: http://www.ejomr.org/JOMR/archives/2021/3/e4/v12n3e4ht.htm |
Received: 1 February 2021 | Accepted: 11 August 2021 | Published: 30 September 2021
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2021.