Cryotherapy T1-T0 T2-T0 T3-T0 T4-T0
Estimate 95% CI SE P Estimate 95% CI SE P Estimate 95% CI SE P Estimate 95% CI SE P
Pain without cryotherapy Reference - - - Reference - - - Reference - - - Reference - - -
with cryotherapy 11.15 0.72; 21.57 5.32 < 0.05 6.87 -0.91; 14.66 3.971 0.083 -7.07 -15.34; 1.19 4.216 0.093 7.5 -5.23; 20.23 6.495 0.248
Trismus without cryotherapy Reference - - - Reference - - - Reference - - - Reference - - -
with cryotherapy - - - - -1.4 -6.41; 3.61 2.554 0.584 3.68 -0.87; 8.23 2.321 0.113 1.45 -12.38; 15.28 7.054 0.837

CI = confidence interval; M3 = mandibular third molar; SE = standard error; VAS = visual analog scale.
Third molars allocated to no cryotherapy were used as reference for the group with cryotherapy.
Pain: assessed by VAS. Estimated value reveals differences in VAS score of pain in millimetres with cryotherapy compared with no cryotherapy.
Trismus: assessed by a ruler. Estimated value shows how many mm the incisal distance has increased or decreased compared to no cryotherapy.
Mean difference in pain and trismus were analyzed with a generalized estimating equation (GEE) analysis for repeated observations.