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Inflammatory Response to Cobalt-Chromium Alloys Fabricated With Different Techniques J Oral Maxillofac Res 2021;12(4):e3 doi:10.5037/jomr.2021.12403 Abstract | HTML | PDF | XML |
Inflammatory Response to Cobalt-Chromium Alloys Fabricated With Different Techniques
1Department of Prosthodontics/Dental Materials Science, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Box 450, SE 405 30 Göteborg, Sweden.
2Department of Prosthetic Dentistry, Institute for Postgraduate Dental Education, Jönköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
3Department of Oral Microbiology and Immunology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
4Dental Clinic, Folktandvården Sörmland AB, The Mälar Hospital, SE-631 88 Eskilstuna, Sweden and Centre for Clinical Research Sörmland, Uppsala University, Eskilstuna, Sweden.
Corresponding Author:
Department of Prosthodontics/Dental Materials Science, Institute of Odontology
The Sahlgrenska Academy, University of Gothenburg
Box 450, SE 405 30 Göteborg
Sweden
Phone: +46-31-786 00 00
E-mail: maria.kassapidou@gu.se
ABSTRACT
Objectives: To explore the in vitro cytokine expression of human peripheral blood mononuclear cells exposed to cobalt-chromium alloys, manufactured with different techniques, in comparison with commercially pure titanium grade 4 and titanium alloy grade 23.
Material and Methods: Peripheral blood mononuclear cells (PBMC) were collected from 10 healthy blood donors and exposed to machine-ground coin-shaped: (a) cobalt-chromium (Co-Cr) specimens (n = 5) manufactured by four techniques, i.e. cast, milled, laser melted and presintered milled; (b) commercially pure titanium grade 4; and (c) titanium alloy grade 23. The cells were cultured for 4, 24 and 72 hours followed by investigations of pro- and anti-inflammatory cytokine release using Bio-Plex Pro™.
Results: In general, the PBMC produced significantly more cytokines when exposed to the cast and presintered milled Co-Cr materials compared to laser melted, milled Co-Cr and titanium materials.
Conclusions: Within the limitation of the present study, it may be suggested that cast and presintered milled cobalt-chromium alloys provoke a stronger inflammatory response compared to milled and laser melted cobalt-chromium alloys and titanium materials.
J Oral Maxillofac Res 2021;12(4):e3
doi: 10.5037/jomr.2021.12403
Accepted for publication: 29 December 2021
Keywords: cobalt-chromium alloys; cytokine; dental casting technique; inflammation; prosthodontics; titanium.
To cite this article: Inflammatory Response to Cobalt-Chromium Alloys Fabricated With Different Techniques J Oral Maxillofac Res 2021;12(4):e3 URL: http://www.ejomr.org/JOMR/archives/2021/4/e3/v12n4e3ht.htm |
Received: 9 December 2021 | Accepted: 29 December 2021 | Published: 31 December 2021
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2021.