Q1 Was true randomization used for assignment of participants to treatment groups?
Q2 Was allocation to treatment groups concealed?
Q3 Were treatment groups similar at the baseline?
Q4 Were participants blind to treatment assignment?
Q5 Were those delivering treatment blind to treatment assignment?
Q6 Were outcomes assessors blind to treatment assignment?
Q7 Were treatment groups treated identically other than the intervention of interest?
Q8 Was follow up complete and if not, were differences between groups in terms of their follow up adequately described and analysed?
Q9 Were participants analysed in the groups to which they were randomized?
Q10 Were outcomes measured in the same way for treatment groups?
Q11 Were outcomes measured in a reliable way?
Q12 Was appropriate statistical analysis used?
Q13 Was the trial design appropriate, and any deviations from the standard RCT design (individual randomization, parallel groups) accounted for in the conduct and analysis of the trial?