Study Population Gender Age Study group Observation period Treatment outcome Results Conclusions
Male/female Years Months
Sim et al. [14] Patients diagnosed with stage 1 - 3 MRONJ underwent subcutaneous teriparatide or placebo injections. Control: 10/9 Control: 64 Control (n = 19): treated with subcutaneous saline injections 12 Treatment was considered successful if had complete resolution of lesion which assessed by CBCT, 3D Slicer measure change in bone volumes, bone mineral density and F-fluoride PET-CT imaging was performed to measure osteoblastic responses to teriparatide Control: 33.3% of lesions resolved by 52 weeks Teriparatide was associated with a greater rate of resolution of MRONJ lesions compared with placebo (P = 0.013)
Test: 8/7 Test: 64 Test (n = 15): treated with subcutaneous teriparatide 20 mg injection. Total: 47 MRONJ lesions Test: 45.4% of lesions resolved by 52 weeks
Ristow et al. [19] Patients diagnosed with stage 1 MRONJ underwent conservative treatment of MRONJ. 33/42 Male: 67.5
female: 68.9 		75 patients with 92 lesions were treated with antimicrobial mouth rinse, 0.2% chlorhexidine solution used three times per day, and 1% chlorhexidine gel applied topically every day 12 - 60 Treatment was considered successful if had complete mucosal coverage without signs of infection Mucosal coverage: 8 lesions (8.7%).
Exposed jaw bone: 84 lesions (91.3%) 		Conservative therapy in stage 1 MRONJ leads to a healing in rare cases

MRONJ = medication-related osteonecrosis of the jaw; CBCT = conical-beam computerized tomography; PET-CT = positron emission tomography/computed tomography.