Study Population Gender Age Study group Observation
period 		Treatment outcome Results Conclusions
Male/female Years Months
Eguchi et al. [16] Patients diagnosed with stage 2 MRONJ and treated with non-surgical or surgical therapy Surgical:
13/15 		Surgical:
72.3 (SD 11.3) 		Surgical (n = 28): necrotic bone resection until the bone tissue's vascularization was established 6 Success-complete absence of exposed bone without any clinical symptoms.
Failure- bone exposure remaining or disease progress 		Surgical:
25 success,
3 failure 		In comparison to non-surgical treatment, surgical treatment for stage 2 MRONJ improved efficacy (P < 0.01)
Non-surgical:
9/15 		Non-surgical:
74.8 (SD 10.3) 		Non-surgical (n = 24): antibiotics and analgesics, as well as professional oral hygiene management by a dental hygienist Non-surgical:
8 success,
16 failure
El-Rabbany et al. [19] Patients diagnosed with stage 1 - 3 MRONJ and treated with non-surgical or surgical therapy Surgical:
9/47 		Surgical:
79 		Surgical (n = 56): debridement, curettage, sequestrectomy, saucerization and resection Surgical:
15.5 		Treatment was considered successful if had absence of pain and absence of exposed or probable bone. Surgical:
39 healed (70%),
17 unhealed (30%) 		Compared to non-surgical therapy, surgical therapy was substantially related with higher odds of resolution
Non-surgical:
5/17 		Non-surgical:
82 		Non-surgical (n = 22): local and/or systemic antimicrobial therapy, pentoxifylline, hyperbaric oxygen and teriparatide Non-surgical:
11 		Non-surgical:
8 healed (36%),
14 unhealed (64%)

MRONJ = medication-related osteonecrosis of the jaw; SD = standard deviation.