Can CAPRIN-1 Be Responsible for the Recurrence Potential of Odontogenic Keratocysts?

Yildirimyan, Nelli; Altay, Mehmet Ali; Özbudak, İrem Hicran

doi:10.5037/jomr.2024.15204

e4	Can CAPRIN-1 Be Responsible for the Recurrence Potential of Odontogenic Keratocysts? Nelli Yildirimyan, Mehmet Ali Altay, İrem Hicran Özbudak J Oral Maxillofac Res 2024;15(2):e4 doi:10.5037/jomr.2024.15204 Abstract \| HTML \| PDF \| XML

Can CAPRIN-1 Be Responsible for the Recurrence Potential of Odontogenic Keratocysts?

Nelli Yildirimyan¹, Mehmet Ali Altay², İrem Hicran Özbudak³

¹Department of Oral and Maxillofacial Surgery, School of Dentistry, Istanbul Medipol University, Istanbul, Türkiye.

²Department of Oral and Maxillofacial Surgery, School of Dentistry, Akdeniz University, Antalya, Türkiye.

³Department of Pathology, School of Medicine, Akdeniz University, Antalya, Türkiye.

Corresponding Author:

Nelli Yildirimyan

Istanbul Medipol Universitesi

Birlik Mah. Bahçeler Cad. No:5 Esenler/İstanbul 34231

Türkiye

Phone: +90-535-748-6808

E-mail: nelli.yildirimyan@medipol.edu.tr

Get Citation

Your browser does not support inline frames or is currently configured not to display inline frames.<br />

Copyright and Permissions

Copyright © Yildirimyan N, Altay MA, Özbudak İH. Published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH (http://www.ejomr.org), 30 June 2024.
This is an open-access article, first published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH, distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work and is properly cited. The copyright, license information and link to the original publication on (http://www.ejomr.org) must be included.

ABSTRACT

Objectives: The purpose of this retrospective study is to compare dentigerous cysts and odontogenic keratocysts for cytoplasmic activation/proliferation - associated protein-1 antibodies via immunohistochemical staining to obtain a new perspective about the specific behavioural characteristics of odontogenic keratocysts at the molecular level.

Material and Methods: Forty dentigerous cysts (DC) and forty odontogenic keratocysts (OKC) tissue samples were examined using immunohistochemical staining to detect cytoplasmic activation/proliferation - associated protein-1 (CAPRIN-1) antibodies. Nuclear and/or cytoplasmic staining was evaluated as “positive”. Cell staining rate (%) and cell staining intensity were determined, and a staining intensity distribution (SID) score was calculated for each sample. Cases were considered “negative” if they showed no staining for CAPRIN-1 antibodies, thus were given a SID score of zero. According to the SID scores, the expression levels were rated as negative, mild, moderate, or high.

Results: Of 80 samples, 16 that could adversely affect immunohistochemical evaluation were excluded. Ten negative, 21 positive and three negative, 30 positive CAPRIN-1 expressions were observed in DC and OKC groups, respectively. The difference between the negative and positive cases within groups was significant only in the OKC group (P = 0.000). The SID score range and mean were 0 to 160 and 31.1 (SD 35.7) for DC and 0 to 160 and 57.3 (SD 42.3) for OKC groups. CAPRIN-1 expression was significantly higher in the OKC group (P = 0.043).

Conclusions: The molecular basis for increased mitotic activity, high recurrence rates or presence of satellite cysts in odontogenic keratocysts may be attributed to the expression of cytoplasmic activation/proliferation - associated protein-1.

J Oral Maxillofac Res 2024;15(2):e4

doi: 10.5037/jomr.2024.15204