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Evaluation of Osteocalcin Level in Gingival Crevicular Fluid in Periodontal Intrabony Defects Treated with Autologous Platelet Rich Fibrin: Non-Randomized Experimental Study J Oral Maxillofac Res 2024;15(4):e3 doi:10.5037/jomr.2024.15403 Abstract | HTML | PDF |
Evaluation of Osteocalcin Level in Gingival Crevicular Fluid in Periodontal Intrabony Defects Treated with Autologous Platelet Rich Fibrin: Non-Randomized Experimental Study
1Department of Periodontics, Vydehi Institute of Dental Sciences and Research Centre, Bangalore, Karnataka, India.
Corresponding Author:
Department of Periodontics
Vydehi Institute of Dental Sciences and Research Centre
82, Nallurahalli Main Rd, near BMTC 18th Depot, Vijayanagar,
Nallurhalli, Whitefield, Bengaluru, Karnataka 560066
India
Phone: +919886824276
E-mail: docshruthi1984@gmail.com
ABSTRACT
Objectives: The aim of this non-randomized experimental study is to evaluate and correlate the gingival crevicular fluid osteocalcin levels with clinical and radiographic parameters in patients with intrabony defects treated with autologous platelet-rich fibrin.
Material and Methods: Thirty intrabony defects in 14 patients were treated with autologous platelet-rich fibrin with open flap debridement. Clinical and radiographic parameters were recorded at baseline and 9 months postsurgery. Gingival crevicular fluid (GCF) was collected prior to the surgery, 3 months, 6 months and 9 months postsurgery and was analysed for levels of osteocalcin using ELISA.
Results: All the clinical and radiographic parameters like plaque index (2.41 to 1.38) and gingival index (2.37 to 1.4) scores, probing pocket dept (6.43 to 3.78 mm), clinical attachment level (7.25 to 4.61 mm), relative attachment level (10.35 to 7.42 mm) and vertical depth (7.46 to 4.9), alveolar crest height (6.2 to 5.9), area of the defect (17.8 to 14.5) respectively showed improvement which was statistically significant (P < 0.001) except for the defect width (8.86 to 8.77) with P = 0.39. A moderate negative correlation was established between the GCF osteoclcin levels and the clinical and radiographic parameters at baseline and 9 months except for the % of defect fill which showed moderate positive correlation at 9 months (r = 0.55, P = 0.002).
Conclusions: The gingival crevicular fluid osteocalcin can serve as a potential bone turnover biomarker in periodontal regeneration. In addition platelet-rich fibrin has made it possible to define natural bone regeneration as well as improve the clinical and radiological parameters.
J Oral Maxillofac Res 2024;15(4):e3
doi: 10.5037/jomr.2024.15403
Accepted for publication: 28 December 2024
Keywords: biomarkers; gingival crevicular fluid; osteocalcin; platelet-rich fibrin; regeneration.
To cite this article: Evaluation of Osteocalcin Level in Gingival Crevicular Fluid in Periodontal Intrabony Defects Treated with Autologous Platelet Rich Fibrin: Non-Randomized Experimental Study J Oral Maxillofac Res 2024;15(4):e3 URL: http://www.ejomr.org/JOMR/archives/2024/4/e3/v15n4e3ht.htm |
Received: 25 August 2024 | Accepted: 28 December 2024 | Published: 31 December 2024
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2024.