Patient and population (P) Adult patients (> 18 years) with conditions requiring bone regeneration after tooth extraction
Intervention (I) Application of local simvastatin for patients after tooth extraction with conditions requiring bone regeneration
Comparison (C) No statin use, placebo, or alternative treatments
Outcomes (O) The effect of statins on bone regeneration, pain and swelling
Focus question There is any improvement of bone regeneration, pain and swelling after tooth extraction with application of local statins?