Prevalence of Peri-implant Diseases in Patients with Osteoporosis: a Systematic Review

Objectives: This systematic review aimed to determine the prevalence of peri-implant diseases in patients affected by osteoporosis rehabilitated with dental implants.

Material and Methods: An electronic search was conducted in the MEDLINE (PubMed), EMBASE, Scopus, and Web of Science databases up to April 2025, complemented by a manual search of the reference lists from the full-text studies. The search included observational studies that identified peri-implantitis and/or peri-implant mucositis in patients affected by osteoporosis rehabilitated with dental implants. The risk of bias was assessed using the Newcastle-Ottawa tool.

Results: A total of 10, from 321, articles were included, and the reported evaluation periods after implant placement ranged from 3 to 11 years. Regardless of age, sex, number of implants, implant location, or duration of oral bisphosphonate use, all studies investigating the presence of mucositis and/or peri-implantitis reported no higher prevalence compared to systemically healthy patients. The prevalence of peri-implantitis was found to be 22%, and peri-implant mucositis 20%, in patients affected by osteoporosis.

Conclusions: Within the limits of this systematic review, it is concluded that osteoporosis does not increase the prevalence of peri-implant diseases or dental implant failure.

J Oral Maxillofac Res 2025;16(3):e1

doi: 10.5037/jomr.2025.16301

Accepted for publication: 30 September 2025

Keywords: age-related osteoporosis; osteoporosis; peri-implantitis; postmenopausal bone loss; prevalence.