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Long-term Assessment of Oral Health-Related Quality of Life Following Surgical Removal of Mandibular Third Molar with Advanced Platelet-rich Fibrin: a Single-blinded Randomized Controlled Trial J Oral Maxillofac Res 2026;17(1):e1 doi:10.5037/jomr.2026.17101 Abstract | HTML | PDF |
Long-term Assessment of Oral Health-Related Quality of Life Following Surgical Removal of Mandibular Third Molar with Advanced Platelet-rich Fibrin: a Single-blinded Randomized Controlled Trial
1Department of Oral and Maxillofacial Surgery, Aalborg University Hospital, Aalborg, Denmark.
2Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
3Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
4Faculty of Medicine, Aalborg University, Aalborg, Denmark.
5Reserach Data and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.
6Department of Gastroenterology & Hepatology, Mech-Sense, Aalborg University Hospital, Aalborg, Denmark.
7Steno Diabetes Center North Denmark, Clinical Institute, Aalborg University Hospital, Aalborg, Denmark.
Corresponding Author:
Department of Oral and Maxillofacial Surgery, Aalborg University HospitalHobrovej 18-22, 9000 Aalborg, Denmark
Phone: +45 23 26 63 70
E-mail: thomas.jensen@rn.dk
ABSTRACT
Objectives: The aim of this single-blinded randomized controlled trial was to test the hypothesis of no difference in long-term oral health-related quality of life following surgical removal of an impacted mandibular third molar with advanced platelet-rich fibrin (test) compared with natural socket healing (control).
Material and Methods: Eighty patients were randomly allocated to test or control. Patient demographic, mouth opening, wound heling, and neurosensory function were assessed at enrolment (T0), 10 days (T1), 30 days (T2), and one-year (T3) after surgery. Oral health-related quality of life (OHRQoL) was evaluated by OHIP-14 and SF-36 questionnaires.
Results: There was no statistically significant difference between test and control in patient demographic, mouth opening, and wound heling at T0-T3, as well as oral health impact profile-14 (OHIP-14) at T1, T2, and T3 (P = 0.35; P = 0.086; P = 0.19), or SF-36 at T3 (P = 0.85). OHIP-14 score was significantly higher at T1 compared with T0 in test and control (P < 0.001), indicating impaired OHRQoL immediately after surgical removal of an impacted mandibular third molar, whereas OHIP-14 score was significant lower in test and control at T3 compared with T0 (P < 0.001), indicating improved long-term OHRQoL. SF-36 score was significantly higher at T3 compared with T0 in control (P = 0.009), indicating improved OHRQoL, while test revealed no significant difference (P = 0.79).
Conclusions: This study demonstrates that surgical removal of an impacted mandibular third molar is associated with long-term improvement in oral health-related quality of life. However, application of advanced platelet-rich fibrin in the extraction socket does not have a beneficial effect on oral health-related quality of life compared with natural socket healing.
J Oral Maxillofac Res 2026;17(1):e1
doi: 10.5037/jomr.2026.17101
Accepted for publication: 28 March 2026
Keywords: patient reported outcome measures; randomized controlled trial; surgery; surveys and questionnaires; third molar; quality of life.
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To cite this article: Long-term Assessment of Oral Health-Related Quality of Life Following Surgical Removal of Mandibular Third Molar with Advanced Platelet-rich Fibrin: a Single-blinded Randomized Controlled Trial J Oral Maxillofac Res 2026;17(1):e1 URL: http://www.ejomr.org/JOMR/archives/2026/1/e1/v17n1e1ht.htm |
Received: 26 February 2026 | Accepted: 28 March 2026 | Published:31 March 2026
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2026.